Evidence map›Paper›PMID 41443299›Full record

ArticleMucosal immunology2026

Wheat fiber-induced peripheral regulatory T-cells suppress development of colitis.

Seong-Eun G Kim, Hirohito Abo, Yanling Wang, Shawn Winer, Daniel A Winer, Michael Pellizzon, Vu L Ngo, Andrew T Gewirtz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mucosal immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Seong-Eun G KimCenter for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, United States.
Hirohito AboCenter for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, United States.
Yanling WangCenter for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, United States.
Shawn WinerDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Daniel A WinerDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Buck Institute for Research on Aging, Novato, CA, United States; Division of Cellular & Molecular Biology, Diabetes Research Group, Toronto General Hospital Research Institute (TGHRI), University Health Network, Toronto, ON M5G 1L7, Canada; Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada.
Michael PellizzonResearch Diets, Inc., New Brunswick, NJ, United States.
Vu L NgoCenter for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, United States.
Andrew T GewirtzCenter for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, United States. Electronic address: agewirtz@gsu.edu.

Funding

Pathophysiology of TLR5KO ColitisR01DK083890 · NIDDK · GEORGIA STATE UNIVERSITY · PI GEWIRTZ, ANDREW T · 2010 to 2023
$5.0M
DECONSTRUCTING INFLAMMATION AND ALTERED MICROBIOTA IN METABOLIC SYNDROMER01DK099071 · NIDDK · GEORGIA STATE UNIVERSITY · PI GEWIRTZ, ANDREW T · 2013 to 2024
$4.8M
NIDDK NIH HHS R01 DK083890NIDDK NIH HHS R01 DK099071
6 · The paper itself

Abstract

Reduced dietary fiber intake is associated with, and may have contributed to, the post-mid-20th century increase in immune-mediated chronic inflammatory diseases, including inflammatory bowel disease (IBD). Reduced fiber intake has resulted, in part, from increased consumption of highly refined foods including those made from white flours, generation of which involves removal of much of the fiber naturally present in wheat kernels. Accordingly, we hypothesized that wheat fiber (WF) might protect against chronic inflammatory diseases. We tested this notion in a murine T-cell-transfer colitis model. Rag1

Indexed as

ColitisDietary FiberT-Lymphocytes, RegulatoryTriticumAdoptive TransferAnimalsDisease Models, AnimalForkhead Transcription FactorsGastrointestinal MicrobiomeHomeodomain ProteinsHumansMiceMice, Inbred C57BLMice, KnockoutDietary FiberForkhead Transcription FactorsHomeodomain ProteinsRAG-1 proteinDietary fiberInflammatory bowel diseaseMetabolitesMicrobiota

Identifiers

PMID41443299
PMCPMC13274533

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.