ArticleThe journals of gerontology. Series B, Psychological sciences and social sciences2025
Multidimensional determinants of active and healthy aging trajectories: a position paper from the Age-It Research Program.
Article in The journals of gerontology. Series B, Psychological sciences and social sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Barriers and facilitators of health information seeking behavior among older adults: a mixed-methods systematic review using the COM-B model.Frontiers in public health · 2026Pooled it
- Aging well in an aging society: Italy at the forefront of global aging and the Age-It Research Program.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectivesThis position paper presents perspectives from Spoke 4 (Trajectories for Active and Healthy Aging) of the Age-It Research Program, which adopts a One Health perspective to examine the interplay of cognitive, behavioral, nutritional, social, and environmental determinants of aging. Addressing these multidimensional factors is crucial to promoting health, independence, and well-being across the life course.
methodsWe reviewed evidence on lifelong determinants of aging, including physical activity, nutrition, mental engagement, and social participation, alongside emerging digital health solutions. The One Health framework guided our analysis, emphasizing the interconnectedness of individual, societal, and environmental influences. Spoke 4 integrates multidisciplinary expertise to translate scientific knowledge into practical tools for communities, healthcare providers, and policymakers.
resultsEvidence shows that sustained engagement in physical activity, cognitively stimulating activities, and strong social networks supports resilience, reduces frailty, and preserves independence. Tailored nutritional strategies further enhance functional capacity. Digital technologies-such as mobile apps, wearable devices, and online platforms-demonstrate potential to improve disease prevention and health monitoring. However, disparities in digital literacy and access remain significant barriers, particularly for older adults. DISCUSSION: Spoke 4 of Age-It highlights the need for multidimensional, One Health-based strategies that integrate traditional health determinants with digital innovations. By combining evidence-based interventions with user-centered e-health platforms, scalable and inclusive solutions can be developed to support healthy aging. These efforts provide policymakers and healthcare systems with tools to foster resilience, mitigate frailty, and enhance quality of life in aging populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.