ArticleThe journals of gerontology. Series B, Psychological sciences and social sciences2025
Clinical and environmental factors, functional status, and multimorbidity-stratifying progression and prognosis of multimorbidity, frailty, and disability: the Age-It Research Program.
Article in The journals of gerontology. Series B, Psychological sciences and social sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Community-dwelling older persons' level of functional ability and heat-related vulnerability: results from the Heat-Health Action Plan study in Cologne, Germany.BMC geriatrics · 2026Article
- Aging well in an aging society: Italy at the forefront of global aging and the Age-It Research Program.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectivesThis paper describes the methodology and activities of the third thematic challenge (Spoke 3) of the Age-It program. Spoke 3 aims to address the clinical complexity and heterogeneity of older subjects' phenotypes through an interdisciplinary biomedical approach.
methodsSpoke 3 will investigate biomarkers related to multimorbidity and frailty, develop prognostic algorithms using novel methodological approaches, including artificial intelligence (AI) techniques to combine biological and clinical data, and identify management strategies for complex older subjects with multimorbidity and frailty. These activities will be realized by launching new prospective longitudinal studies and through new analyses of existing longitudinal cohorts.
resultsSpoke 3 is expected to generate original evidence concerning older subjects with multimorbidity and/or frailty, to support a more precise diagnostic evaluation, to improve the ability to predict the functional and cognitive trajectories, with the final aim of better managing this complex population. Spoke 3 also aims to evaluate the impact of climate change and pollution on the health status of older subjects by combining health and environmental data. DISCUSSION: Overcoming the traditional medical approach, focused on the diagnosis and treatment of single diseases, Spoke 3 should provide important original evidence to improve the management of older subjects with multimorbidity and frailty.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.