ArticleThe journals of gerontology. Series B, Psychological sciences and social sciences2025
Improving our understanding of the biology of aging: findings from the Age-It Research Program.
Article in The journals of gerontology. Series B, Psychological sciences and social sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Aging well in an aging society: Italy at the forefront of global aging and the Age-It Research Program.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Positive demography: changing the perspective on population aging from the Age-It Research Program.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectivesAging mechanisms at both cellular and organismal levels remain poorly understood, as do the factors influencing the variability in aging rates across organs and individuals. Our work aims to identify the key biological pathways that drive aging, determine the most relevant biomarkers of biological aging, and uncover actionable mechanisms to improve risk prediction for unsuccessful aging.
methodsTo achieve these objectives, we employ a structured approach that includes (a) investigating the molecular and cellular mechanisms underlying aging, (b) identifying and validating biomarkers associated with biological aging, and (c) assessing potential therapeutic targets that could modulate aging-related processes. These efforts are being carried out within the framework of the Age-It initiative, leveraging interdisciplinary methodologies and advanced analytical tools.
resultsOngoing studies within Age-It are generating insights into aging-related pathways and biomarkers. Preliminary findings highlight specific molecular signatures associated with biological aging and suggest potential intervention points for mitigating age-related decline. DISCUSSION: Understanding the biological underpinnings of aging will enhance our ability to predict and potentially modify aging trajectories. By identifying reliable biomarkers and actionable pathways, this research may contribute to the development of targeted interventions to promote healthy aging. The Age-It initiative represents a collaborative effort to translate these findings into practical applications for aging research and health care policy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.