ArticleACS applied bio materials2026
Small Intestine-Targeted Long-Acting Oral Insulin Formulation Based on Engineered Milk Protein Nanoparticles.
Anbu Mozhi Thamizhchelvan, Yuancheng Li, Jonathan Padelford, Ce Yang, Chunhua Yang, Peijian He, Ashan Galhena, Tianhe Wu, Malgorzata Lipowska, Hui Mao
Abstract read
In one paragraphArticle in ACS applied bio materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors.
Anbu Mozhi ThamizhchelvanDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, United States.ORCID 0000-0002-8840-6667 Yuancheng LiDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, United States.ORCID 0000-0001-7410-0176 Jonathan Padelford5M Biomed, LLC, Atlanta, Georgia 30303, United States.
Ce Yang5M Biomed, LLC, Atlanta, Georgia 30303, United States.
Chunhua YangInstitute for Biomedical Sciences, Georgia State University, Atlanta, Georgia 30303, United States.ORCID 0000-0003-0805-1008 Peijian HeDepartment of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, United States.
Ashan GalhenaDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, United States.
Tianhe WuDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, United States.
Malgorzata LipowskaDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, United States.
Hui MaoDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, United States.ORCID 0000-0002-0147-6022 Funding
Stroma penetrating and immune modulating nanoparticles for image-guided therapy of pancreatic cancerR01CA261251 · NCI · EMORY UNIVERSITY · PI MAO, HUI, YANG, LILY · 2021 to 2025
$2.6MMRI Capable Receptor Targeted Drug Delivery for Pancreatic CancerR01CA154846 · NCI · EMORY UNIVERSITY · PI MAO, HUI, YANG, LILY · 2011 to 2015
$2.1MSmall Intestine Targeted Fast Acting Oral Insulin FormulationR41DK131761 · NIDDK · 5M BIOMED, LLC · PI LI, YUANCHENG, MAO, HUI · 2021 to 2021
$300kNCI NIH HHS R01 CA154846NCI NIH HHS R01 CA261251NIDDK NIH HHS R41 DK131761
6 · The paper itselfAbstract
Insulin therapies remain essential for glycemic control in diabetes mellitus, yet conventional subcutaneous injection is associated with poor patient compliance, risk of hypoglycemia, and other adverse effects. Oral insulin formulations offer a promising alternative by improving patient adherence and mimicking the endogenous insulin pathway. However, their clinical trials, mostly in enteric capsules and tablets, have yielded limited efficacy due to low insulin bioavailability. In this study, we prepared an oral insulin formulation by coencapsulating insulin and the permeation enhancer sodium caprate (C
Indexed as
Biocompatible MaterialsHypoglycemic AgentsInsulinIntestine, SmallMilk ProteinsNanoparticlesAdministration, OralAnimalsCaseinsMaleMaterials TestingMiceParticle SizeBiocompatible MaterialsCaseinsHypoglycemic AgentsInsulinMilk Proteinsdiabetesinsulinlong actingmilk proteinnanoparticleoral delivery
Identifiers
PMID41442621
PMCPMC12820955
What OpenQuestion holds
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LicenceCC BY
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