Evidence map›Paper›PMID 41442063›Full record

ArticleGeroScience2025

Facial skin aging: an integrative analysis of genetics, epigenetics, and lifestyle factors.

Rezvan Noroozi, Aleksandra Pisarek-Pacek, Bożena Wysocka, Kamila Migacz-Gruszka, Paulina Pruszkowska-Przybylska, Magdalena Kobus, Dagmara Lisman, Julia Zacharczuk, Joanna Rudnicka, Aleksandra Iljin and 10 more

Abstract read
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In one paragraph

Article in GeroScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Rezvan NorooziDepartment of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Aleksandra Pisarek-PacekInstitute of Zoology and Biomedical Research of the Jagiellonian University, Krakow, Poland.
Bożena WysockaCentral Forensic Laboratory of the Police, Warsaw, Poland.
Kamila Migacz-GruszkaDepartment of Dermatology, Jagiellonian University Medical College, Krakow, Poland.
Paulina Pruszkowska-PrzybylskaDepartment of Anthropology, University of Lodz, Lodz, Poland.
Magdalena KobusInstitute of Biological Sciences, Faculty of Biology and Environmental Sciences, Cardinal Stefan Wyszynski University in Warsaw, Warsaw, Poland.
Dagmara LismanDepartment of Genomics and Forensic Genetics, Pomeranian Medical University in Szczecin, Szczecin, Poland.
Julia ZacharczukDepartment of Genomics and Forensic Genetics, Pomeranian Medical University in Szczecin, Szczecin, Poland.
Joanna RudnickaMalopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland.
Aleksandra IljinDepartment of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Lodz, Lodz, Poland.
Kathryn C FitzgeraldDepartment of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Małgorzata MichalczykInstitute of Sport Science, The Jerzy Kukuczka Academy of Physical Education in Katowice, Katowice, Poland.
Piotr KaczkaInstitute of Sport Science, The Jerzy Kukuczka Academy of Physical Education in Katowice, Katowice, Poland.
Michał KrzysztofikInstitute of Sport Science, The Jerzy Kukuczka Academy of Physical Education in Katowice, Katowice, Poland.
Maciej KostrzewaInstitute of Sport Science, The Jerzy Kukuczka Academy of Physical Education in Katowice, Katowice, Poland.
Aneta SitekDepartment of Anthropology, University of Lodz, Lodz, Poland.
Magdalena SpólnickaCenter for Forensic Science, University of Warsaw, Warsaw, Poland.
Andrzej OssowskiDepartment of Genomics and Forensic Genetics, Pomeranian Medical University in Szczecin, Szczecin, Poland.
Wojciech BranickiInstitute of Zoology and Biomedical Research of the Jagiellonian University, Krakow, Poland.
Ewelina PośpiechDepartment of Genomics and Forensic Genetics, Pomeranian Medical University in Szczecin, Szczecin, Poland. ewelina.pospiech@pum.edu.pl.ORCID http://orcid.org/0000-0001-8867-0727

Funding

Narodowe Centrum Badań i Rozwoju DOB-BIO10/06/01/2019Narodowe Centrum Nauki 2024/53/B/NZ7/02257
6 · The paper itself

Abstract

Facial wrinkling is a prominent sign of aging, yet individuals exhibit unique trajectories of biological aging, contributing to the variability in facial appearance. Here, we present a pioneering study exploring the association between lifestyle choices, DNA methylation, and SNP genotypes with a range of facial skin aging phenotypes. The study demonstrated that age-related facial skin phenotypes are influenced by multiple environmental stressors. Epigenome-wide association analyses identified differentially methylated cytosines mapped to 151 loci, including novel genes associated with facial wrinkles, such as EDAR (cg02925966, p = 4.96 × 10

Indexed as

Anti-aging strategiesDNA methylation biomarkersEDAREpigenetic ageFacial wrinklingGenomic predictive modellingLifestyleMeQTLPerceived facial ageSkin aging

Identifiers

PMID41442063

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.