ArticleClinical and experimental medicine2025
Prognostic value of memory B cell subpopulation in patients with chronic lymphocytic leukemia.
Article in Clinical and experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Chronic lymphocytic leukemia (CLL) is characterized by aberrant B-cell receptor (BCR) signalling and resistance to apoptosis. Patients with CLL present varied responses to BCR-targeted therapies, this emphasises the need for personalised treatment strategies. The immunophenotype of B cell in patients with CLL may offer valuable insights into disease heterogeneity and immunotherapeutic strategies. In this study, we investigated the prognostic value of B cell subsets in relation to clinical parameters such as Rai stage, β₂-microglobulin (B2M) levels and the Chronic Lymphocytic Leukemia International Prognostic Index (CLL-IPI) in untreated patients with CLL. The levels B cell subsets were measured using multicolor flow cytometry. Interestingly, patients with CLL had significantly increased levels of naïve B cells (p < 0.0001). As expected, patients with CLL had significantly decreased levels of marginal zone B cells (p = 0.0059), non-class switched memory B cells (p = 0.0010), and class switched memory B cells (p < 0.0001). Moreover, after adjusting for age and sex, class-switched memory B cells were positively associated with the Rai stage (β = 0.1455, p = 0.0466). In contrast, non-class switched memory B cells inversely correlated with the Chronic Lymphocytic Leukemia International Prognostic Index (r = -0.79, p = 0.004). These findings suggest that memory B-cell subset profiles may provide valuable prognostic significance in patients with CLL.
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