Evidence map›Paper›PMID 41442046›Full record

ArticleSurgical endoscopy2026

Clinical outcomes of extensive endoscopic submucosal dissection involving more than three-fourths of the circumference for gastric epithelial neoplasia.

Haowen Dai, Jie Zhang, Yun Qian, Chongju Bao, Sha Shi, Qinwei Xu, Guang Yang, Wei Gong, Yiwei Fu, Jianqiu Sheng and 2 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Surgical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Haowen Dai *Medical School of Chinese PLA, Beijing, China.
Jie Zhang *Department of Gastroenterology, the Seventh Medical Center of Chinese PLA General Hospital, Beijing, China.
Yun Qian *Department of Gastroenterology, the Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, Jiangsu, China.
Chongju Bao *Department of Gastroenterology, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, China.
Sha ShiDepartment of Gastroenterology, Liaocheng People's Hospital, Liaocheng, Shandong, China.
Qinwei XuEndoscopy Center, Department of Gastroenterology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Guang YangDepartment of Gastroenterology, South China Hospital, Medical School, Shenzhen University, No.1 Fuxin Road, Pinghu Street, Longgang District, Shenzhen, 518111, China.
Wei GongDepartment of Gastroenterology, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, China.
Yiwei FuDepartment of Gastroenterology, the Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, Jiangsu, China.
Jianqiu ShengSenior Department of Gastroenterology, Chinese PLA General Hospital, No.28 Fuxing Road, Beijing, 100853, China.
Silin HuangDepartment of Gastroenterology, South China Hospital, Medical School, Shenzhen University, No.1 Fuxin Road, Pinghu Street, Longgang District, Shenzhen, 518111, China. silinhuang@szu.edu.cn.
Peng JinSenior Department of Gastroenterology, Chinese PLA General Hospital, No.28 Fuxing Road, Beijing, 100853, China. jinpeng@301hospital.com.cn.ORCID 0000-0001-6685-1906

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was to evaluate the clinical outcomes of extensive submucosal dissection involving more than three-fourths of the circumference (eESD) for gastric epithelial neoplasia.

methodsConsecutive patients treated by eESD for gastric epithelial neoplasia were retrospectively included at 7 medical centers between 2015 and 2025. Short-term outcomes were en bloc resection, R0 resection, curative resection, procedure time, and adverse events, whereas long-term outcomes were local recurrence rate (LRR), simultaneous multiple carcinomas incidence rate (SMCIR), heterochronous multiple carcinomas incidence rate (HMCIR), and cancer metastasis incidence rate (CMIR).

resultsForty-three patients with 47 lesions (median tumor size: 6.0 cm) were analyzed. The en bloc resection, R0 resection, and curative resection rates were 100, 97.9, and 93.6%, respectively. The median procedure time was 115 min. Two patients had postoperative fever (4.7%) and two patients had delayed bleeding (4.7%). Postoperative abdominal pain occurred in 30 patients (69.8%). No patient occurred intraoperative and delayed perforations. Eight patients experienced post-eESD pyloric stenosis (18.6%). Within a median follow-up of 32.0 months, the LRR, SMCIR, HMCIR, and CMIR were 4.7, 2.3, 0.0, and 2.3%, respectively. Transverse extent of the mucosal defect more than 64 mm was a significant risk factor for post-eESD pyloric stenosis (OR: 15.99, 95% CI: 1.56-163.66, P = 0.017). Tumor depth of invasion (submucosal invasion depth ≥ 500 μm) was a significant risk factor for lymphovascular invasion (OR: 71.13, 95% CI: 3.03-1672.42, P = 0.008).

conclusioneESD for gastric epithelial neoplasia might be technically feasible and highly curative treatment.

Indexed as

Endoscopic Mucosal ResectionGastric MucosaGastroscopyStomach NeoplasmsAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedNeoplasm Recurrence, LocalOperative TimePostoperative ComplicationsRetrospective StudiesTreatment OutcomeCurative resectionEndoscopic submucosal dissectionGastric epithelial neoplasiaRisk factorStenosis

Identifiers

PMID41442046

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.