ArticleAdvances in therapy2026
PaCE CKD: A Multinational Survey of Health-Related Quality of Life in Patients with Chronic Kidney Disease and Caregivers.
Article in Advances in therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Impact of chronic kidney disease on adults and their caregivers in the United States: a systematic literature review.BMC nephrology · 2026Pooled it
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionChronic kidney disease (CKD) can negatively impact the quality of life (QoL) of patients and caregivers. Determinants of QoL may vary between countries and healthcare systems. Given the global prevalence of CKD, this multinational study aimed to quantify the impact of CKD on QoL for patients and caregivers worldwide.
methodsPatients with CKD, caregivers and matched general population participants were recruited in Australia, Germany, Egypt, Italy, Mexico, Taiwan, the UK and the US. QoL was assessed by patient and caregiver response to EQ-5D-5L, and also to the CarerQol-7D instrument for caregivers. Subgroups were stratified by dialysis-dependence status.
resultsA total of 1382 patients and 813 caregivers were recruited. Across the surveyed country cohorts, patients reported significantly decreased EQ-5D-5L index scores versus matched general population cohorts (0.57-0.89 vs. 0.93-0.96, respectively; all p < 0.005), with greater impairment in dialysis-dependent patients versus non-dialysis-dependent patients (0.51-0.79 vs. 0.65-0.93, respectively). Patients typically reported significantly greater impairments across all EQ-5D-5L domains versus the general population. Caregivers reported lower mean EQ-5D-5L index scores versus matched general population cohorts (0.73-0.93 vs. 0.93-0.97, respectively). Caregivers reported mean CarerQol-7D index scores between 63.0 and 79.6, with numerically lower scores for caregivers of dialysis-dependent patients.
conclusionThis is the first study that characterises the QoL burden of CKD in patients and caregivers on a multinational scale. Patients and caregivers experience a considerable QoL burden, particularly when dialysis-dependent. Strategies to alleviate burden, including prevention of CKD progression, financial and social supports, are required but may vary according to local context.
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