Evidence map›Paper›PMID 41441988›Full record

ArticleHuman genetics2025

Exploratory analysis of HLA SNPs associated with occult HBV infection: a multicenter case-control study in Chinese blood donors.

Lin Zhou, Ying Yan, Huimin Ji, Huizhen Sun, Zhuoqun Lu, Le Chang, Lunan Wang

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Human genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lin ZhouNational Center for Clinical Laboratories, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology, Beijing, 100730, P.R. China.
Ying YanNational Center for Clinical Laboratories, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology, Beijing, 100730, P.R. China.
Huimin JiNational Center for Clinical Laboratories, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology, Beijing, 100730, P.R. China.
Huizhen SunNational Center for Clinical Laboratories, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology, Beijing, 100730, P.R. China.
Zhuoqun LuNational Center for Clinical Laboratories, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology, Beijing, 100730, P.R. China.
Le ChangNational Center for Clinical Laboratories, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology, Beijing, 100730, P.R. China. changle4652@bjhmoh.cn.
Lunan WangNational Center for Clinical Laboratories, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology, Beijing, 100730, P.R. China. lunan99@163.com.

Funding

CAMS Innovation Fund for Medical Sciences 2021-I2M-1-060National High Level Hospital Clinical Research Funding BJ-2024-195National Natural Science Foundation of China 82202612
6 · The paper itself

Abstract

Occult hepatitis B virus infection (OBI), characterized by detectable HBV DNA but undetectable HBsAg, poses diagnostic and clinical challenges, with host genetic factors, particularly HLA-mediated immune regulation, remaining poorly understood. Through whole-exome sequencing of 147 participants (74 OBI cases, 73 chronic HBsAg + controls), we identified four HLA single nucleotide polymorphisms (SNPs) associated with low OBI susceptibility and proposed a dual immune mechanism: Class I SNPs impair cytotoxic responses, while Class II SNPs dysregulate humoral immunity. Anti-HBs titers and age modulated genetic risk penetrance, with high anti-HBs increasing OBI susceptibility regardless of genotype, and genetic effects attenuating in individuals > 50 years. Integrating HLA genetic markers with serological and baseline characteristics significantly improved OBI susceptibility prediction (AUC 0.93), highlighting the role of HLA-mediated immunity in OBI pathogenesis and the potential of genetic markers for risk stratification in HBV-exposed individuals. Our findings elucidate HLA-mediated immune mechanisms underlying OBI and demonstrate the value of genetic markers in predicting the likelihood of developing OBI or progressing to chronic HBsAg + status among HBV-exposed individuals.

Indexed as

Blood DonorsGenetic Predisposition to DiseaseHepatitis BHLA AntigensPolymorphism, Single NucleotideAdultCase-Control StudiesChinaEast Asian PeopleFemaleGenotypeHepatitis B Surface AntigensHepatitis B virusHumansMaleMiddle AgedHepatitis B Surface AntigensHLA Antigens

Identifiers

PMID41441988

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.