Observational studyEuropean journal of pediatrics2025
Utility of transcranial Doppler and reversed jugular venous saturations for neuromonitoring in children with acute liver failure.
Observational study in European journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Paediatric and adult neurological point-of-care ultrasound: Review of the evidence, and the UK accreditation pathway.Journal of the Intensive Care Society · 2026Article
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8 authors.
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Abstract
Paediatric Acute Liver Failure (PALF) is associated with high morbidity and mortality, with cerebral oedema a key contributor to mortality. The aim of our study was to examine the association between the findings of two neuromonitoring modalities (transcranial Doppler (TCD) and reverse venous jugular oxygen saturation (SjvO
interventionsNone. The median (IQR) age of the study population was 64 (25-144) months. Among the 78 children, 24 (30.8%) survived without liver transplant, 39 children (50.0%) survived post-liver transplant, 5 (6.4%) died post-transplant, and 10 (12.8%) died without transplant. Patients who died had a lower meanvelocity in the right middle cerebral artery (RMCA Vm) (Median: 34 cm/s vs 55 cm/s, p-value: 0.01) and higher pulsatility index (PI) than those who survived (Median: 2.1 vs 1.6, p: 0.001). SjvO
conclusionPatients with acute liver failure who died had a high RMCA PI, lower RMCA Vm, and lower SjvO WHAT IS KNOWN: • Paediatric Acute Liver Failure (PALF) is associated with high morbidity and mortality, with cerebral oedema a key contributor to mortality. • There is little published evidence regarding the use of bedside neuromonitoring techniques like transcranial dopplers and reverse jugular saturations in the paediatric population with acute liver failure. WHAT IS NEW: • In our single-centre experience (2013-2023), neuromonitoring in PALF patients correlates with mortality. Bedside neuromonitoring with TCD and SjvO2 showed a weak correlation with ammonia and between each other. • Future work should focus on the impact of neuromonitoring on delivered neuroprotective strategies and patient outcomes.
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