SynthesisCancer causes & control : CCC2025
The effects of vitamin D levels on risk and prognosis of ovarian cancer: a systematic review.
Synthesis in Cancer causes & control : CCC, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeOvarian cancer is the eighth most common cancer in women with the highest mortality rate of all gynecological cancers. Serum vitamin D level has been explored as a possible modifiable risk factor for development and progression of this disease. The proposed study aims to answer the questions: do women with low levels of vitamin D have a higher risk for developing ovarian cancer and, do low vitamin D levels at the time of ovarian cancer diagnosis predict a poorer prognosis?
methodsA systematic search was performed in PubMed, CINAHL, Cochrane, and Scopus. Cohort, case-control, in vivo, in vitro, and ex vivo studies assessing the effect of vitamin D levels on the risk of developing ovarian cancer, prognosis at time of diagnosis of ovarian cancer, or both, published in English since July of 2008 were included. Eighteen studies were included in this review.
resultsSix of the nine case-control studies found ovarian cancer patients to have lower vitamin D levels. Of the studies to investigate survival rates, both articles reported significant increases in survival rate in vitamin D sufficient patients. Cohort studies found similar mixed results to the case-control experiments, while experimental studies produced significant results pertaining to vitamin D's ability to reduce proliferation and decrease progression in ovarian cancer cell lines. However, two large-scale, nested studies noted no significant association between low vitamin D levels and ovarian cancer incidence.
conclusionThis review has determined that lower vitamin D levels are a risk factor for the development of ovarian cancer. In addition, it was found that ovarian cancer patients with low vitamin D levels have a worse prognosis comparatively.
Indexed as
Identifiers
41441906What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.