ArticleJournal of materials science. Materials in medicine2025
Evaluation of cellular immune response and biosafety of SV40 virus-like particle in tumor immunotherapy.
Article in Journal of materials science. Materials in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
Virus-like particle (VLP) holds great promise for applications in vaccines and tumor immunotherapy. However, their clinical translation has been limited by a lack of comprehensive in vivo studies on immune responses and antigenic toxicity. In this study, we systematically evaluated the efficacy and safety of VLP as immunological agents. We administered Simian Virus 40 (SV40) VLP through subcutaneous injection and analyzed their effects on immune cell populations in key organs. In vivo imaging of mice demonstrated the migration of SV40 VLP between lymph nodes. Flow cytometry revealed that SV40 VLP significantly increased the numbers of CD4
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