ReviewWorld journal of microbiology & biotechnology2025
Recent insights in the importance of limonene and its biotransformed value added compounds.
Review in World journal of microbiology & biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The Influence of Hydroxyl Group on Nerve Excitability Blockade by Limonene and Its Hydroxylated Metabolites, Perillyl Alcohol and Carveol.Molecules (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Limonene is a naturally occurring monocyclic monoterpene that is a substrate for the sustainable production of high-value bioactive compounds for green chemistry, perfumes, cosmetics, and pharmaceuticals. Despite being promising, the application of limonene industrially is limited because of its high volatility, low solubility, and cytotoxic action towards microbial hosts. Value-added compounds such as carveol, carvone, perillyl alcohol, perillic acid, and limonene-1,2-diol are produced from limonene through microbial biotransformation. This review explores the role of bacteria, yeast, and fungi in these bioconversions, detailing key enzymatic reactions like hydroxylation, oxidation, epoxidation, and dihydroxylation. The influence of limonene enantiomers on product formation and specificity of biotransformation is discussed, along with applications of the resulting compounds in therapeutic, aromatic, and industrial domains. It also summarizes current challenges and future opportunities for industrial-scale production, including substrate and product toxicity, limitations of enzymatic reaction, and process scalability. On comparison with earlier reviews that addressed the biological and industrial aspects of limonene separately, this review provides a comprehensive approach that combines metabolic engineering, biosynthesis, microbial biotransformation, and therapeutic potential. It also emphasizes chemoenzymatic methodologies, providing a thorough framework that links biomedical applications with green bioprocessing and highlights new prospects for the industrial valorization of limonene and its derivatives.
Indexed as
Identifiers
41441891What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.