Evidence map›Paper›PMID 41441790›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2026

Eutectozymes as Soft Hybrid Materials for Advanced Biocatalysis.

Manuel Eduardo Martinez Cartagena, Lucia Suarez, Aitor Ontoria, Francisca J Benitez, Elixabete Rezabal, María Soledad Orellano, Marcelo Calderón, Cristián Huck-Iriart, Agustin S Picco, Matias L Picchio and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Manuel Eduardo Martinez CartagenaPOLYMAT, Applied Chemistry Department, Faculty of Chemistry, University of the Basque Country UPV/EHU, Donostia-San Sebastián, Spain.ORCID https://orcid.org/0000-0002-3708-1938
Lucia SuarezPOLYMAT, Applied Chemistry Department, Faculty of Chemistry, University of the Basque Country UPV/EHU, Donostia-San Sebastián, Spain.
Aitor OntoriaPOLYMAT, Applied Chemistry Department, Faculty of Chemistry, University of the Basque Country UPV/EHU, Donostia-San Sebastián, Spain.
Francisca J BenitezDonostia International Physics Center (DIPC) and Polymers and Advanced Materials Department, Faculty of Chemistry, University of the Basque Country UPV/EHU, Donostia-San Sebastián, Spain.ORCID https://orcid.org/0000-0003-2066-2485
Elixabete RezabalDonostia International Physics Center (DIPC) and Polymers and Advanced Materials Department, Faculty of Chemistry, University of the Basque Country UPV/EHU, Donostia-San Sebastián, Spain.ORCID https://orcid.org/0000-0003-0397-6140
María Soledad OrellanoPOLYMAT, Applied Chemistry Department, Faculty of Chemistry, University of the Basque Country UPV/EHU, Donostia-San Sebastián, Spain.ORCID https://orcid.org/0000-0002-4227-999X
Marcelo CalderónPOLYMAT, Applied Chemistry Department, Faculty of Chemistry, University of the Basque Country UPV/EHU, Donostia-San Sebastián, Spain.ORCID https://orcid.org/0000-0002-2734-9742
Cristián Huck-IriartExperiment Division, ALBA Synchrotron Light Source, Carrer de la Llum 2-26, Cerdanyola del Vallès, Barcelona, Spain.ORCID https://orcid.org/0000-0001-5734-2499
Agustin S PiccoInstituto de Investigaciones Fisicoquímicas, Teóricas y Aplicadas (INIFTA), UNLP - CONICET, La Plata, Argentina.ORCID https://orcid.org/0000-0003-4683-7319
Matias L PicchioPOLYMAT, Applied Chemistry Department, Faculty of Chemistry, University of the Basque Country UPV/EHU, Donostia-San Sebastián, Spain.ORCID https://orcid.org/0000-0003-3454-5992
Ana BeloquiPOLYMAT, Applied Chemistry Department, Faculty of Chemistry, University of the Basque Country UPV/EHU, Donostia-San Sebastián, Spain.ORCID https://orcid.org/0000-0002-7693-4163

Funding

Agencia Estatal de Investigación CEX2023-001303-MALBA Synchrotron Light source, Barcelona, Spain 2023027439Euskal Herriko UnibertsitateaEusko Jaurlaritza IT1766-22Fundación Ramón Areces CIVP22S18625HORIZON EUROPE Marie Sklodowska-Curie Actions MSCA-SE 101129945Spanish Research Agency CNS2023-145416Spanish Research Agency PID2022-142128NB-I00University of the Basque Country
6 · The paper itself

Abstract

The development of soft hybrid materials that combine structural integrity, biocompatibility, and catalytic function is a central challenge in advanced biocatalysis. Here, we introduce eutectozymes, enzyme-loaded eutectogels built from natural hydrophobic deep eutectic solvents (HES) and stabilized through a dual supramolecular polymeric network. This unique architecture not only preserves the conformational integrity of enzymes but also creates confined microcavities acting as protective microreactors, thereby enhancing their stability and substrate affinity. Eutectozymes exhibit remarkable resilience under harsh operational conditions, including high temperatures, extreme pH, and organic solvents, while maintaining high catalytic efficiency and reusability. Their versatility is further demonstrated in environmental remediation, achieving over 90% degradation of recalcitrant dyes, and in antimicrobial applications against resistant bacterial strains. By synergistically merging the stabilizing properties of HES with robust gel matrices, eutectozymes establish a transformative platform for heterogeneous biocatalysis, opening new avenues in biotechnology, bioelectronics, and environmental technologies.

Indexed as

BiocatalysisEnzymes, ImmobilizedDeep Eutectic SolventsHydrogen-Ion ConcentrationHydrophobic and Hydrophilic InteractionsSolventsTemperatureDeep Eutectic SolventsEnzymes, ImmobilizedSolventsbiocatalysisdeep eutectic solventsenzyme immobilizationeutectogelseutectozymes

Identifiers

PMID41441790
PMCPMC13569024

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.