Evidence map›Paper›PMID 41441742›Full record

ArticleAngewandte Chemie (International ed. in English)2026

Strain-Release Induced 1,2-Metallate Rearrangement of Geminal Diborons: Multicomponent 1,5-Difunctionalization via Ring-Opening Coupling.

Ashvin J Gangani, Het Vyas, Aiswarya Mini, Dharmraj Pathak, Darius Marian, Abhishek Sharma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Borylcyclopropanes: Synthetic Strategies and Applications.Angewandte Chemie (International ed. in English) · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ashvin J GanganiDepartment of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ, USA.
Het VyasDepartment of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ, USA.
Aiswarya MiniDepartment of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ, USA.
Dharmraj PathakDepartment of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ, USA.
Darius MarianDepartment of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ, USA.
Abhishek SharmaDepartment of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ, USA.ORCID https://orcid.org/0000-0001-6070-4403

Funding

Novel Acylborons and Alpha-hydroxy Borons to Enable Modular, Regio- and Stereocontrolled Synthesis of Bioactive Molecules and Protein ConjugatesR35GM143091 · NIGMS · THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY · PI SHARMA, ABHISHEK · 2021 to 2025
$1.5M
Modular Approaches to Unusual Borylated Heterocycles using Novel Acylborons and alpha-Hydroxy borons as Enabling ToolsR15GM135891 · NIGMS · THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY · PI SHARMA, ABHISHEK · 2020 to 2020
$463k
NIGMS NIH HHS R15 GM135891NIGMS NIH HHS R35 GM143091NIH-NIGMS R15GM135891NIH-NIGMS R35GM143091
6 · The paper itself

Abstract

1,2-metallate rearrangement of geminal diboryl alkanes typically requires an α-leaving group and results in monofunctionalization at the proximal carbon. We present a strategy to engage non-terminal geminal diborons in 1,2-boronate shift via ring-opening of strained vinyl cyclopropyl diborons (VCPDBs). This multicomponent reaction enabled proximal and remote 1,5-difunctionalization yielding densely functionalized homoallylic diboryl alkanes featuring allylic halide or branched 1,5-diene motifs which are components of bioactive natural products. The VCPDB reaction displayed polarity inversion relative to majority of the previous VCP ring-opening reactions. The protocol showed broad substrate scope, providing alkenyl products with high E-stereoselectivity, and their downstream synthetic utility was also demonstrated. Employing a chiral ligand in the allylation preserved the reaction efficiency while indicating enantioenrichment in the ring-opening coupling.

Indexed as

1,2 Boronate shiftAllylationGeminal diboryl alkaneStrain releaseSynthetic Methods

Identifiers

PMID41441742
PMCPMC12742564

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.