Immunogenicity of a Lipopolysaccharide

Alnakhli Naseer, Steven C Olsen, Salman Mo, Joshua B Daniels, Brian McCluskey

Abstract read

In one paragraph

Article in Vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alnakhli NaseerAnimal Population Health Institute, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Campus Stop 1644, Fort Collins, CO 80523, USA.

Steven C OlsenInfectious Bacterial Diseases Research Unit, National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, IA 50010, USA.ORCID 0000-0002-4136-3831

Salman MoAnimal Population Health Institute, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Campus Stop 1644, Fort Collins, CO 80523, USA.ORCID 0000-0001-5982-6331

Joshua B DanielsDepartment of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.

Brian McCluskeyAnimal Population Health Institute, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Campus Stop 1644, Fort Collins, CO 80523, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background

methodsIn this study, we evaluated the immunologic responses and protection against experimental challenge in 18 goats vaccinated with either lipopolysaccharide (LPS) from

resultsGoats (

conclusionsOur data suggests that LPS + ISA 61 VG induces a robust humoral response but negligible cellular responses. Our data also suggest that LPS + ISA 61 VG or LPS alone would not be efficacious for use as a vaccine in goats, but the LPS + ISA 61 VG inoculum may be beneficial as a booster. Additional trials would be necessary to evaluate the vaccine's efficacy as a booster inoculation for small ruminants.

Indexed as

Brucella melitensisbrucellosisexperimental challengegoatshumoral and cellular immunityLPS vaccine

Identifiers

PMID41441675

DOI10.3390/vaccines13121209

PMCPMC12737732

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.