Evidence map›Paper›PMID 41441627›Full record

ArticleToxins2025

Correlations Between Trimethylamine-N-Oxide, Megalin, Lysine and Markers of Tubular Damage in Chronic Kidney Disease.

Stefania Kapetanaki, Samira Salihovic, Ashok Kumar Kumawat, Ziad A Massy, Katarina Persson, Peter Barany, Peter Stenvinkel, Marie Evans, Isak Demirel

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In one paragraph

Article in Toxins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Stefania KapetanakiSchool of Medical Sciences, Örebro University, Campus USÖ, 701 82 Örebro, Sweden.
Samira SalihovicSchool of Medical Sciences, Örebro University, Campus USÖ, 701 82 Örebro, Sweden.
Ashok Kumar KumawatSchool of Medical Sciences, Örebro University, Campus USÖ, 701 82 Örebro, Sweden.ORCID 0000-0002-2244-9816
Ziad A MassyDepartment of Nephrology, Ambroise Paré University Hospital, APHP, Boulogne-Billancourt, F-92100 Paris, France.
Katarina PerssonSchool of Medical Sciences, Örebro University, Campus USÖ, 701 82 Örebro, Sweden.ORCID 0009-0006-2517-034X
Peter BaranyDepartment of Clinical Science, Intervention and Technology, Division of Renal Medicine, Karolinska Institutet, 141 52 Stockholm, Sweden.ORCID 0000-0001-6501-8293
Peter StenvinkelDepartment of Clinical Science, Intervention and Technology, Division of Renal Medicine, Karolinska Institutet, 141 52 Stockholm, Sweden.ORCID 0000-0002-8785-4820
Marie EvansDepartment of Clinical Science, Intervention and Technology, Division of Renal Medicine, Karolinska Institutet, 141 52 Stockholm, Sweden.
Isak DemirelSchool of Medical Sciences, Örebro University, Campus USÖ, 701 82 Örebro, Sweden.

Funding

European Renal Association NASwedish Knowledge Foundation NASwedish Medical Association NA
6 · The paper itself

Abstract

Trimethylamine-N-oxide (TMAO), a gut microbiota-derived dietary metabolite, is linked to progression of chronic kidney disease (CKD). Megalin, a renal proximal tubule receptor crucial for albumin reabsorption, also plays a role in CKD. However, the relationship between them is not well explored. The aim of this study was to investigate if there are any correlations between the levels of TMAO, megalin, lysine and markers of tubular damage in CKD. Urinary metabolites (TMAO, choline, L-carnitine, betaine, lysine) and tubular markers (megalin, albumin, EGF, MCP-1) were quantified by LC-MS/MS and ELISA. Associations were evaluated using analysis of covariance (ANCOVA) adjusted for age and diabetes, with false discovery rate correction. Compared with controls, CKD patients showed higher urinary choline (FDR < 0.001), betaine (FDR = 0.007), lysine (FDR = 0.005), and soluble megalin (FDR < 0.001) but lower EGF and EGF/MCP-1 ratio (both FDR < 0.001). Correlation analyses revealed that serum TMAO was positively associated with soluble megalin and negatively with EGF/MCP-1 ratio. Choline, L-carnitine, and betaine were positively correlated with megalin. This cross-sectional study identifies associations between urinary metabolites, megalin, and tubular injury markers in advanced CKD. Although causality cannot be inferred, the results point to a potential metabolic-tubular link that should be explored in future longitudinal and mechanistic studies.

Indexed as

Low Density Lipoprotein Receptor-Related Protein-2LysineMethylaminesRenal Insufficiency, ChronicAdultAgedBiomarkersEpidermal Growth FactorFemaleHumansMaleMiddle AgedBiomarkersEpidermal Growth FactorLow Density Lipoprotein Receptor-Related Protein-2LRP2 protein, humanLysineMethylaminestrimethyloxaminealbuminuriachronic kidney diseaselysinemegalinTMAOtubular damage

Identifiers

PMID41441627
PMCPMC12737579

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.