Evidence map›Paper›PMID 41441615›Full record

ReviewToxins2025

Ion Channel-Targeting Toxins: Structural Mechanisms of Activation, Inhibition, and Therapeutic Potential.

Narumi Aoki-Shioi, Shuhei Nomura, Yasuyoshi Tanaka, Shinichi Hirose

Abstract readReview
In one paragraph

Review in Toxins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Narumi Aoki-ShioiDepartment of Medical Technology, Faculty of Fukuoka Medical Technology, Teikyo University, 6-22 Misakimachi, Omuta 836-8505, Fukuoka, Japan.ORCID 0000-0001-8326-6856
Shuhei NomuraDepartment of Medical Technology, Faculty of Fukuoka Medical Technology, Teikyo University, 6-22 Misakimachi, Omuta 836-8505, Fukuoka, Japan.ORCID 0009-0003-3467-6885
Yasuyoshi TanakaDepartment of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, 19-1 8-chome, Nanakuma, Jonan-ku, Fukuoka 814-0180, Fukuoka, Japan.
Shinichi HiroseGeneral Medical Research Center School of Medicine, Fukuoka University, 45-1 7-chome Nanakuma Jonan-ku, Fukuoka 814-0180, Fukuoka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Toxins as channel probes, small guanidinium alkaloids, such as tetrodotoxin and saxitoxin, canonical pore occlusion in voltage-gated Na

Indexed as

Ion Channel GatingIon ChannelsAnimalsBacterial ToxinsHumansBacterial ToxinsIon Channelscryo-EMgating modifierion channel toxinspeptide toxinspore blockadestate-dependent modulationvoltage-sensor domain (VSD)

Identifiers

PMID41441615
PMCPMC12737659

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.