Evidence map›Paper›PMID 41441569›Full record

ReviewTropical medicine and infectious disease2025

Dengue and Acute Pancreatitis: A Systematic Review.

Matteo Riccò, Antonio Cascio, Luca Pipitò, Marco Bottazzoli, Paolo Manzoni, Lilian Romina Brandolisio, Cecilia Nobili, Pasquale Gianluca Giuri

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Tropical medicine and infectious disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Matteo RiccòAUSL-IRCCS di Reggio Emilia, Servizio di Prevenzione e Sicurezza Negli Ambienti di Lavoro (SPSAL), Local Health Unit of Reggio Emilia, 42122 Reggio Emilia, Italy.ORCID 0000-0002-6525-2159
Antonio CascioInfectious and Tropical Diseases Unit, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, "G D'Alessandro", University of Palermo, AOUP P. Giaccone, 90127 Palermo, Italy.ORCID 0000-0002-1992-1796
Luca PipitòInfectious and Tropical Diseases Unit, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, "G D'Alessandro", University of Palermo, AOUP P. Giaccone, 90127 Palermo, Italy.
Marco BottazzoliDepartment of Otorhinolaryngology, APSS Trento, 38122 Trento, Italy.ORCID 0000-0003-0888-9521
Paolo ManzoniSCDU Pediatria e Neonatologia, Ospedale Degli Infermi, Ponderano (BI), Dipartimento Materno-Infantile, Local Health Unit of Biella (ASLBI), University of Torino, 10124 Torino, Italy.
Lilian Romina BrandolisioSCDU Pediatria e Neonatologia, Ospedale Degli Infermi, Ponderano (BI), Dipartimento Materno-Infantile, Local Health Unit of Biella (ASLBI), University of Torino, 10124 Torino, Italy.
Cecilia NobiliSCDU Pediatria e Neonatologia, Ospedale Degli Infermi, Ponderano (BI), Dipartimento Materno-Infantile, Local Health Unit of Biella (ASLBI), University of Torino, 10124 Torino, Italy.ORCID 0009-0001-5112-8982
Pasquale Gianluca GiuriDepartment of Medicine and Diagnostics, AUSL di Parma, 43100 Parma, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dengue fever typically presents as a febrile illness, and acute pancreatitis has been reported as a rare complication. Limited evidence exists regarding clinical features, imaging findings, and outcomes, particularly on the distinction between acute interstitial pancreatitis and acute necrotizing pancreatitis. This systematic review was therefore designed in accordance with PRISMA guidelines (PROSPERO ID: CRD420250631013) in order to characterize the clinical spectrum of dengue virus (DENV)-associated acute pancreatitis by recollecting available case reports from PubMed, EMBASE, Scopus, MedRxiv, and BioRxiv Case reports and case series, which were included if they described laboratory-confirmed DENV infection and met the diagnostic criteria for acute pancreatitis. Seventy cases of DENV-associated acute pancreatitis were identified, mostly from Asia (78.6%) and South America (17.1%). Patients were predominantly male (62.9%), with a mean age of 31.6 years. Acute interstitial pancreatitis was more common (65.7%) than acute necrotizing pancreatitis (34.3%). Acute necrotizing pancreatitis was associated with leukocytosis, pancreatic collections, multiorgan and respiratory failure, prolonged hospital stay, and higher mortality (25.0% vs. 4.3% for acute interstitial pancreatitis). Overall, the case fatality was 11.4%, and survival analysis demonstrated significantly worse outcomes for acute necrotizing pancreatitis. In summary, clinicians should maintain awareness of this complication, as early recognition and appropriate management may improve outcomes.

Indexed as

acute interstitial pancreatitisacute necrotizing pancreatitisacute pancreatitisdengue

Identifiers

PMID41441569
PMCPMC12737391

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.