ArticleNanomaterials (Basel, Switzerland)2025
Antimicrobial Proteinoid Nanostructures via Thermal Condensation of L-Glutamic Acid and L-Tyrosine.
Marta Cadeddu, James R G Adams, Roberto La Ragione, Daniel K Whelligan, Vlad Stolojan, Nadia Bernardi, Ioannis Smyrnias, Barbara Poddesu, Giulia Cugia, Davide De Forni and 4 more
Abstract read
In one paragraphArticle in Nanomaterials (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
14 authors.
Marta CadedduLaboratory of Materials Science and Nanotechnology, CR-INSTM, Department of Engineering, University of Sassari, Via Vienna 2, 07100 Sassari, Italy.ORCID 0009-0000-5287-834X James R G AdamsDiscipline of Comparative Biomedical Sciences, School of Veterinary Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7AL, UK.ORCID 0000-0002-3415-2999 Roberto La RagioneDiscipline of Comparative Biomedical Sciences, School of Veterinary Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7AL, UK.ORCID 0000-0001-5861-613X Daniel K WhelliganSchool of Chemistry and Chemical Engineering, University of Surrey, Guildford GU2 7YH, UK.ORCID 0000-0002-7792-1874 Vlad StolojanAdvanced Technology Institute (ATI), School of Computer Science and Electronic Engineering, University of Surrey, Guildford GU2 7YH, UK.ORCID 0000-0003-1137-4043 Nadia BernardiDiscipline of Comparative Biomedical Sciences, School of Veterinary Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7AL, UK.ORCID 0009-0007-4110-8981 Ioannis SmyrniasDiscipline of Comparative Biomedical Sciences, School of Veterinary Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7AL, UK.ORCID 0000-0001-6422-938X Barbara PoddesuViroStatics S.r.l., Viale Umberto I, 46, 07100 Sassari, Italy.
Giulia CugiaViroStatics S.r.l., Viale Umberto I, 46, 07100 Sassari, Italy.
Luca MalfattiLaboratory of Materials Science and Nanotechnology, CR-INSTM, Department of Engineering, University of Sassari, Via Vienna 2, 07100 Sassari, Italy.ORCID 0000-0001-6901-8506 Davide CarboniLaboratory of Materials Science and Nanotechnology, CR-INSTM, Department of Engineering, University of Sassari, Via Vienna 2, 07100 Sassari, Italy.ORCID 0000-0003-2499-4567 Alessandra PinnaDiscipline of Comparative Biomedical Sciences, School of Veterinary Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7AL, UK.ORCID 0009-0001-4467-8484 Plinio InnocenziLaboratory of Materials Science and Nanotechnology, CR-INSTM, Department of Engineering, University of Sassari, Via Vienna 2, 07100 Sassari, Italy.ORCID 0000-0003-2300-4680 Funding
e.INS-Ecosystem of Innovation for Next Generation Sardinia funded by Italian Ministry for Research and Education under the National Recovery and Resilience Plan (NRRP) MISSION 4 COMPO-NENT 2, "From research to business" INVESTMENT 1.5, "Creation and stren ECS 00000038Surrey Future Fellowship (SFF) funds Surrey Future Fellowship (SFF) funds
6 · The paper itselfAbstract
The synthesis of biocidal peptide materials using simple, low-cost, solvent-free methods is a crucial challenge for developing new antimicrobial approaches. In this study, we produced proteinoid nanostructures through simple, inexpensive, and environmentally friendly thermal reactions between glutamic acid (Glu) and tyrosine (Tyr) in various molar ratios. Mechanistically, the thermal cyclization of glutamic acid into pyroglutamic acid (pGlu) facilitated the formation of short peptide chains containing pGlu as the
Indexed as
antimicrobial peptidesL-glutamic acidL-tyrosinenanomaterialsproteinoidsStaphylococcus
Identifiers
PMID41441460
PMCPMC12736111
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