Evidence map›Paper›PMID 41441435›Full record

ArticleSports (Basel, Switzerland)2025

Molecular, Systemic, and Physiological Adaptations to High-Intensity Interval Training in Flatwater Kayak Athletes.

Apostolos Papandreou, Georgios Tzanis, Athanasios Moustogiannis, Evangelos Zevolis, Elias Zacharogiannis, Maria Maridaki, Serafim Nanas, Michael Koutsilieris, Anastassios Philippou

Abstract read
In one paragraph

Article in Sports (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Apostolos PapandreouDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Georgios TzanisFirst Critical Care Medicine Department, "Evangelismos" Hospital, National and Kapodistrian University of Athens, 10679 Athens, Greece.
Athanasios MoustogiannisDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.ORCID 0000-0002-1441-4664
Evangelos ZevolisDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Elias ZacharogiannisSchool of Physical Education and Sport Science, National and Kapodistrian University of Athens, 17237 Athens, Greece.
Maria MaridakiSchool of Physical Education and Sport Science, National and Kapodistrian University of Athens, 17237 Athens, Greece.ORCID 0000-0003-3458-4633
Serafim NanasFirst Critical Care Medicine Department, "Evangelismos" Hospital, National and Kapodistrian University of Athens, 10679 Athens, Greece.ORCID 0000-0003-4666-4550
Michael KoutsilierisDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Anastassios PhilippouDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.ORCID 0000-0003-0047-3003

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeHigh-intensity interval training (HIIT) has emerged as a time-efficient alternative to traditional endurance training. This study investigated the molecular, systemic, and physiological adaptations induced by an 8-week HIIT program in national-level flatwater kayak athletes.

methodsSix trained male kayakers completed an 8-week HIIT intervention. Skeletal muscle biopsies and venous blood samples were collected before and after training to assess markers related to endocrine function, growth and remodeling, angiogenesis, and inflammation. Physiological and performance measures were evaluated using a maximal oxygen uptake (VO

resultsHIIT elicited significant improvements across molecular, systemic, and performance parameters. Post-training analyses showed increased expression of IGF-1R, MMP-4, MMP-9, and TNF-α (

conclusionsAn 8-week HIIT program effectively enhanced molecular signaling, systemic adaptation, and sport-specific performance in elite flatwater kayak athletes. The concurrent upregulation of anabolic, remodeling, and inflammatory pathways suggests that HIIT facilitates coordinated muscular and systemic adaptations beneficial for kayak performance.

Indexed as

flatwater kayakhigh intensity interval traininghormonal responsesphysiological adaptationssystemic adaptations

Identifiers

PMID41441435
PMCPMC12736612

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.