Assessing Perfluorooctane Sulfonate (PFOS) Toxicity and Carcinogenicity Through Zebrafish (

Tessa Block, Joan Renee DeMaio, Lela Skopec, Margaret Ayers, Eric Glasgow

Abstract read

In one paragraph

Article in Toxics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tessa BlockDepartment of Oncology, Georgetown University, 4000 Reservoir Road, Washington, DC 20057, USA.ORCID 0009-0002-8332-0538

Joan Renee DeMaioDepartment of Oncology, Georgetown University, 4000 Reservoir Road, Washington, DC 20057, USA.ORCID 0009-0009-2744-7439

Lela SkopecDepartment of Oncology, Georgetown University, 4000 Reservoir Road, Washington, DC 20057, USA.

Margaret AyersDepartment of Oncology, Georgetown University, 4000 Reservoir Road, Washington, DC 20057, USA.

Eric GlasgowDepartment of Oncology, Georgetown University, 4000 Reservoir Road, Washington, DC 20057, USA.ORCID 0000-0001-7729-3954

Funding

Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI STEPHEN W BYERS · 1990 to 2026

$71.5M

NCI NIH HHS P30 CA051008NIH/NCI CCSG P30-CA051008

6 · The paper itself

Abstract

Persistent environmental pollutants such as per- and poly-fluoroalkyl substances (PFAS) have been associated with a wide range of toxic effects, including cancer. There are over 12,000 PFAS compounds, which may act as carcinogens individually or in combinations. Therefore, efficient in vivo new approach models of carcinogenicity are needed for evaluating environmental contaminant compounds and chemical mixtures. Here, we use the larval zebrafish xenograft assay to identify tumor growth activity of perfluorooctane sulfonate (PFOS), a known carcinogenic PFAS. Dose-response curves for PFOS exposure were used to identify the Maximum Tolerated Concentration (MTC) and Lethal Concentration causing 50% death (LC

Indexed as

ACHNCaki-1carcinogeniccontaminantsenvironmentalLC50MTCNAMPFASPFOSpollutantsxenograftzebrafish

Identifiers

PMID41441298

DOI10.3390/toxics13121077

PMCPMC12737301

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.