ReviewToxics2025
Understanding Target-Specific Effects of Antidepressant Drug Pollution on Molluscs: A Systematic Review Report.
Review in Toxics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Antidepressant drugs (ADDs) are one of the most widely prescribed pharmaceuticals globally and are widely detected in the environment. They are designed to target monoamine neurotransmission-a highly conserved pathway between humans and animal species. Monoamines are particularly involved in the regulation of a wide array of key biological functions in molluscs, an ecologically important group of animals. Despite this, the target-specific effects of environmental concentrations of different classes of ADDs in molluscs remain poorly understood. The present study seeks to understand the target-specific effects of environmental concentrations of different classes of ADDs in molluscs through a systematic review of the literature. This study, following our published systematic review protocol, analyzed 51 studies after deduplication and screening of 1156 identified records. Included studies reported on a range of outcomes, including reproductive, (loco)motor, developmental, behavioral, immuno-modulating and neurophysiological effects. Data synthesis was performed with a harvest plot of exposures, effect direction and risk of bias. We found evidence (weak to moderate) for (i) immunosuppression, resulting from tissue serotonin level elevation, (ii) larval development impairment, and (iii) acetylcholinesterase inhibition, at environmental concentrations of ADDs. Most study outcomes, in addition to data-deficient outcomes, were inconclusive due largely to methodological limitations such as the use of wild-derived species with minimal or no acclimation (65.38% of included studies), lack of proper controls and replicates, and unrealistic exposures, affecting the reliability of existing data. Although the observed effects-particularly immunosuppressive ones-provide critical insight into the ecological risks posed by ADDs, their impacts at environmentally relevant concentrations remain poorly characterized for most endpoints. Given the ecological importance of molluscs, further studies addressing the identified methodological and research gaps are urgently needed to better characterize the hazards posed by environmental concentrations of ADDs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.