ArticleToxics2025
Dimethyl Sulfoxide as a Biocompatible Extractant for Enzymatic Bioluminescent Toxicity Assays: Experimental Validation and Molecular Dynamics Insights.
Article in Toxics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
Funding
Abstract
Diesel fuel is among the most persistent petroleum-derived pollutants in soils, posing long-term ecological and toxicological risks, especially in cold-climate regions where natural degradation is limited. Reliable assessment of diesel-contaminated soils remains difficult because conventional solvent-based analyses are incompatible with bioassays, while aqueous extracts underestimate hydrocarbon toxicity. This study evaluated dimethyl sulfoxide (DMSO) as a biocompatible extractant for enzymatic bioluminescent toxicity assays employing the coupled NAD(P)H:FMN-oxidoreductase and bacterial luciferase (BLuc-Red) system. Soil samples artificially contaminated with diesel fuel were analyzed using DMSO extracts in combination with molecular dynamics (MD) simulations to examine enzyme stability in solvent environments. Moderate DMSO concentrations (4-6%
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