Evidence map›Paper›PMID 41441105›Full record

ArticleGels (Basel, Switzerland)2025

Construction and Activity of Cisplatin-Loaded Chitosan-Zinc Amino-Porphyrin Photosensitizer Hydrogel.

Hongmei Zhang, Dongqing Li, Pengge Wang, Yunxia Yang, Daliang Zhu, Yanqing Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gels (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hongmei ZhangSchool of Chemical and Environmental Engineering, Yancheng Teachers University, Yancheng 224007, China.
Dongqing LiSchool of Chemical and Environmental Engineering, Yancheng Teachers University, Yancheng 224007, China.
Pengge WangSchool of Chemical and Environmental Engineering, Yancheng Teachers University, Yancheng 224007, China.
Yunxia YangSchool of Chemical and Environmental Engineering, Yancheng Teachers University, Yancheng 224007, China.
Daliang ZhuSchool of Chemical and Environmental Engineering, Yancheng Teachers University, Yancheng 224007, China.
Yanqing WangSchool of Chemical and Environmental Engineering, Yancheng Teachers University, Yancheng 224007, China.

Funding

National Natural Science Foundation of China 22172138Science and Technology Program of Yancheng YCBK2024042
6 · The paper itself

Abstract

Cisplatin resistance remains a major impediment to the successful chemotherapy of various solid tumors, including ovarian, lung, and head and neck cancers. Diverse drug delivery systems with photodynamic specificity significantly target diseased cells precisely. Herein, a homogeneous photodynamic hydrogel drug-loading network based on chitosan (CS) containing zinc amino-porphyrin (ZnTAPP) has been developed for carrying cisplatin (CDDP). Aldehyde groups of glutaraldehyde acted as a bridge to connect ZnTAPP and CS. CDDP was then loaded in CS-ZnTAPP hydrogel to construct the anticancer drug system synergistically. Multiple analysis methods were applied to evaluate the chemical structure and physical properties of hydrogels, including a Fourier transform infrared spectrometer, scanning electron microscopy, an X-ray powder diffractometer, rheological measurements, etc. CS-ZnTAPP hydrogels as well as CS-ZnTAPP-CDDP hydrogels, generated abundant singlet oxygen rapidly for photodynamic therapy. Finally, the hydrogels exhibited significant anticancer activities under irradiation; the IC50 was reduced to 10.936 μg/mL toward CDDP-resistant lung cancer cells (A549/CDDP). The new hydrogel could be applied as a photodynamic anticancer drug delivery system to overcome cisplatin resistance.

Indexed as

chitosandrug deliveryphotodynamic hydrogelplatinum-based drug

Identifiers

PMID41441105
PMCPMC12732534

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.