Evidence map›Paper›PMID 41441015›Full record

ArticleMetabolites2025

Zinc-Related Proteasome Variants in Type 1 Diabetes: An in Silico-Guided Case-Control Study.

Raif Gregorio Nasre-Nasser, Anna Carolina Meireles Vieira, Felipe Mateus Pellenz, Luciane Moretto, Eliandra Girardi, Taís Silveira Assmann, Chih-Hao Lu, Luís Henrique Canani, Cristine Dieter, Daisy Crispim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Raif Gregorio Nasre-NasserGraduate Program in Medical Sciences: Endocrinology, Faculty of Medicine, Department of Internal Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-000, Rio Grande do Sul, Brazil.ORCID 0000-0002-8350-1008
Anna Carolina Meireles VieiraEndocrine Division, Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-003, Rio Grande do Sul, Brazil.ORCID 0009-0000-4901-5199
Felipe Mateus PellenzEndocrine Division, Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-003, Rio Grande do Sul, Brazil.
Luciane MorettoGraduate Program in Medical Sciences: Endocrinology, Faculty of Medicine, Department of Internal Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-000, Rio Grande do Sul, Brazil.
Eliandra GirardiEndocrine Division, Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-003, Rio Grande do Sul, Brazil.
Taís Silveira AssmannGraduate Program in Medical Sciences: Endocrinology, Faculty of Medicine, Department of Internal Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-000, Rio Grande do Sul, Brazil.
Chih-Hao LuInstitute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University, Hsinchu 300093, Taiwan.
Luís Henrique CananiGraduate Program in Medical Sciences: Endocrinology, Faculty of Medicine, Department of Internal Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-000, Rio Grande do Sul, Brazil.
Cristine DieterGraduate Program in Medical Sciences: Endocrinology, Faculty of Medicine, Department of Internal Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-000, Rio Grande do Sul, Brazil.
Daisy CrispimGraduate Program in Medical Sciences: Endocrinology, Faculty of Medicine, Department of Internal Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-000, Rio Grande do Sul, Brazil.ORCID 0000-0001-5095-9269

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Level 1BCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) 001Financiamento e Incentivo à Pesquisa at HCPA (FIPE-HCPA) 2022-0156Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (FAPERGS) 0Partnerships Program for Education and Training (PAEC) from the Organization of American States (OAS) and the Coimbra Group of Brazilian Universities (GCUB) 0
6 · The paper itself

Abstract

introductionThe proteasome is a multicatalytic complex responsible for protein degradation and regulation of immune responses, and has been implicated in type 1 diabetes mellitus (T1DM) pathogenesis. Zinc (Zn

methodsThis case-control study included 654 patients with T1DM and 573 subjects without DM from Southern Brazil. SNPs were selected through in silico analysis using MIB docking platform to identify Zn

resultsThe

conclusionsThe

Indexed as

kidney diseaseproteasomePSMA6PSMB9PSMC6PSMD3retinopathysingle nucleotide polymorphismT1DMzinc

Identifiers

PMID41441015
PMCPMC12734831

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.