ReviewMetabolites2025
The Crosstalk Between Brain Energy Metabolism and Neuropathic Pain: Mechanisms and Therapeutic Implications.
Review in Metabolites, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Astrocytes in Neuropathic Pain: Mechanistic and Global Insights.Pain research & management · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Normal physiological brain activity relies on precise and orderly energy supply. The brain's complex energy metabolism (encompassing glucose, lipid, lactate, and amino acid metabolic pathways) underpins neuronal function. Neuropathic pain severely impacts patients' quality of life, and traditional therapies often prove ineffective. This condition is frequently accompanied by energy metabolism disorders in relevant brain regions. Dysregulation of metabolic pathways disrupts neuronal energy supply and signaling, impairs synaptic transmission, and triggers abnormal glial interactions and neuroinflammation, thereby driving the onset and chronic progression of neuropathic pain. This paper systematically elucidates the impact of metabolic pathway imbalances on neuropathic pain and explores potential therapeutic strategies targeting energy homeostasis. It aims to provide novel theoretical foundations and treatment approaches for the clinical management of neuropathic pain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.