Evidence map›Paper›PMID 41440982›Full record

ReviewJournal of personalized medicine2025

Gene Therapy for Inherited Retinal Disease: Current Strategies, Personalized Medicine, and Future Implications-A Comprehensive Review.

Fahad R Butt, Thanansayan Dhivagaran, Boaz Li, Mark Ashamalla, Brendan K Tao, Michael Balas, Austin Pereira, Peng Yan, Parnian Arjmand

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of personalized medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Vascular regeneration and blood flow recovery in glaucoma.Frontiers in cell and developmental biology · 2026
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fahad R ButtSchulich School of Medicine & Dentistry, University of Western Ontario, London, ON N6A 5B8, Canada.ORCID 0009-0004-1025-4765
Thanansayan DhivagaranSchulich School of Medicine & Dentistry, University of Western Ontario, London, ON N6A 5B8, Canada.ORCID 0000-0003-0571-2894
Boaz LiFaculty of Medicine, The University of British Columbia, Vancouver, BC V6T 1Z4, Canada.ORCID 0000-0002-6834-9466
Mark AshamallaFaculty of Medicine, The University of British Columbia, Vancouver, BC V6T 1Z4, Canada.ORCID 0009-0002-8427-5484
Brendan K TaoDepartment of Ophthalmology & Vision Sciences, University of Toronto, Toronto, ON M5S 1A1, Canada.ORCID 0000-0001-7069-3162
Michael BalasDepartment of Ophthalmology & Vision Sciences, University of Toronto, Toronto, ON M5S 1A1, Canada.
Austin PereiraDepartment of Ophthalmology & Vision Sciences, University of Toronto, Toronto, ON M5S 1A1, Canada.
Peng YanDepartment of Ophthalmology & Vision Sciences, University of Toronto, Toronto, ON M5S 1A1, Canada.
Parnian ArjmandDepartment of Ophthalmology & Vision Sciences, University of Toronto, Toronto, ON M5S 1A1, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gene therapy represents a transformative frontier in ophthalmology, offering the potential to address inherited and acquired retinal diseases at their genetic origin rather than through symptomatic management. By introducing exogenous genetic material to restore or modulate gene expression, gene therapy aims to preserve or even restore vision in patients with mutations that disrupt normal retinal function. The eye's small, compartmentalized structure, relative immune privilege, and direct accessibility through subretinal or intravitreal routes make it an ideal target for localized delivery with minimal systemic exposure. The approval of voretigene neparvovec-rzyl for

Indexed as

gene therapyhereditary retinal diseasesintravitreal gene therapysubretinal gene delivery

Identifiers

PMID41440982
PMCPMC12734377

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.