Evidence map›Paper›PMID 41440878›Full record

ReviewJournal of cardiovascular development and disease2025

Echocardiographic Assessment of Patients Undergoing Mitral Valve Repair.

Marco Rolando, Nadeem Elmasry, Federico Gobbi, Antonella Moreo, Nina Ajmone Marsan, Erberto Carluccio, Federico Fortuni

Abstract readReview
In one paragraph

Review in Journal of cardiovascular development and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marco RolandoIndependent Researcher, 63100 Ascoli Piceno, Italy.ORCID 0000-0001-8928-8626
Nadeem ElmasryDepartment of Cardiology, Leiden University Medical Centre (LUMC), Albinusdreef 2, 2300 RC Leiden, The Netherlands.ORCID 0009-0008-3313-9611
Federico GobbiCardiology and Cardiovascular Pathophysiology, S. Maria Della Misericordia Hospital, University of Perugia, Piazzale Menghini 1, 06129 Perugia, Italy.
Antonella MoreoDepartment of Cardiology, De Gasperis Cardio Center, ASST Grande Ospedale Metropolitano Niguarda, Piazza dell'Ospedale Maggiore 3, 20162 Milan, Italy.ORCID 0000-0003-3150-3885
Nina Ajmone MarsanDepartment of Cardiology, Leiden University Medical Centre (LUMC), Albinusdreef 2, 2300 RC Leiden, The Netherlands.ORCID 0000-0001-7208-5769
Erberto CarluccioCardiology and Cardiovascular Pathophysiology, S. Maria Della Misericordia Hospital, University of Perugia, Piazzale Menghini 1, 06129 Perugia, Italy.ORCID 0000-0002-9296-4397
Federico FortuniCardiology and Cardiovascular Pathophysiology, S. Maria Della Misericordia Hospital, University of Perugia, Piazzale Menghini 1, 06129 Perugia, Italy.ORCID 0000-0001-6905-9439

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitral regurgitation (MR) is one of the most prevalent valvular disorders worldwide, with a growing burden driven by population aging and improved diagnostic capabilities. Understanding the mechanism of MR, whether primary, due to intrinsic valve abnormalities, or secondary, resulting from atrial or ventricular remodeling, is essential for optimal management. Echocardiography, particularly advanced modalities such as three-dimensional imaging and strain analysis, plays a central role in this process. It allows accurate quantification of MR severity, detailed characterization of valve and ventricular anatomy, and assessment of remodeling, all of which are critical for determining the optimal timing for intervention. Beyond diagnosis, echocardiography is indispensable in guiding therapy selection: it informs surgical planning by defining leaflet pathology for repair versus replacement strategies, and directs transcatheter interventions by guiding interatrial septal puncture, catheter orientation, and device deployment in real time. While surgery remains the gold standard for primary MR, transcatheter approaches including edge-to-edge repair and emerging mitral valve replacement are increasingly relevant, particularly in patients at high surgical risk or with complex anatomy. This review emphasizes the pivotal role of echocardiography in the pre-procedural assessment of MR, highlighting its ability to integrate anatomical, functional, and hemodynamic information to guide patient-tailored therapeutic strategies and optimize outcomes within a Heart Team framework.

Indexed as

mitral regurgitationmultidisciplinary approachmultimodality imagingthree-dimensional echocardiographytranscatheter edge-to-edge repairtranscatheter mitral valve intervention

Identifiers

PMID41440878
PMCPMC12733537

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.