Evidence map›Paper›PMID 41440871›Full record

ArticleJournal of cardiovascular development and disease2025

Genetic and Clinical Characterization of FLNC Variants in Chinese Patients with Cardiomyopathy.

Guofeng Xing, Li Chen, Lizhi Lv, Chengming Hu, Shengmei Liu, Yabing Duan, Jiachen Li, Qiang Wang, Xiaoyan Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular development and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Guofeng XingDepartment of Pediatric Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, No.2 Anzhen Street, Chaoyang District, Beijing 100029, China.
Li ChenDepartment of Pediatric Cardiology, Beijing Anzhen Hospital, Capital Medical University, No.2 Anzhen Street, Chaoyang District, Beijing 100029, China.
Lizhi LvDepartment of Pediatric Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, No.2 Anzhen Street, Chaoyang District, Beijing 100029, China.
Chengming HuDepartment of Pediatric Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, No.2 Anzhen Street, Chaoyang District, Beijing 100029, China.
Shengmei LiuDepartment of Pediatric Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, No.2 Anzhen Street, Chaoyang District, Beijing 100029, China.
Yabing DuanDepartment of Pediatric Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, No.2 Anzhen Street, Chaoyang District, Beijing 100029, China.
Jiachen LiDepartment of Pediatric Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, No.2 Anzhen Street, Chaoyang District, Beijing 100029, China.
Qiang WangDepartment of Pediatric Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, No.2 Anzhen Street, Chaoyang District, Beijing 100029, China.
Xiaoyan LiBeijing Institution of Heart Lung and Blood Vassal Diseases, Beijing Anzhen Hospital, Capital Medical University, No.2 Anzhen Street, Chaoyang District, Beijing 100029, China.

Funding

Capital's Funds for Health Improvement and Research CRF-2024-1-2062Noncommunicable Chronic Diseases-National Science and Technology Major Project 2023ZD0514400Science and Technology Innovation Fund-Major Science and Technology Innovation Research and Development Special Project KCZD202202
6 · The paper itself

Abstract

This study investigates FLNC mutations in Chinese cardiomyopathy patients. Background: Inherited cardiomyopathies, including dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM), restrictive cardiomyopathy (RCM), and arrhythmogenic right ventricular cardiomyopathy (ARVC) are major heart failure causes. FLNC, critical for muscle structure, is implicated in myofibrillar myopathy and isolated DCM (3-4% cases) with ventricular arrhythmias. Missense variants are linked to HCM and protein aggregation. A cohort of 25 patients with pathogenic/likely pathogenic FLNC mutations (2022-2025, Beijing Anzhen Hospital) underwent whole-exome sequencing (WES) using IDT kit 1.0/Hiseq 4000. Variants were classified via the American College of Medical Genetics and Genomics (ACMG) guidelines. Clinical data (echocardiography, CMR, labs) and follow-up data (prognosis, meds, and family history) were collected. The statistics used SPSS (

Indexed as

cardiomyopathiesfilaminsFLNC

Identifiers

PMID41440871
PMCPMC12734206

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