Evidence map›Paper›PMID 41440755›Full record

ReviewJournal of xenobiotics2025

A Systematic Review on the Toxicology of European Union-Approved Triazole Fungicides in Cell Lines and Mammalian Models.

Constantina-Bianca Vulpe, Adina-Daniela Iachimov-Datcu, Andrijana Pujicic, Bianca-Vanesa Agachi

Abstract readReview
In one paragraph

Review in Journal of xenobiotics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Electrochemical Sensors for Pesticide Residue Detection.Molecules (Basel, Switzerland) · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Constantina-Bianca VulpeDepartment of Scientific Research in Biology, Advanced Environmental Research Institute, West University of Timisoara, Oituz 4, 300086 Timisoara, Romania.ORCID 0009-0004-9229-2529
Adina-Daniela Iachimov-DatcuThe Academy of Romanian Scientists, Ilfov 3, 050044 Bucharest, Romania.ORCID 0000-0001-7229-718X
Andrijana PujicicThe Academy of Romanian Scientists, Ilfov 3, 050044 Bucharest, Romania.ORCID 0009-0007-7571-8083
Bianca-Vanesa AgachiThe Academy of Romanian Scientists, Ilfov 3, 050044 Bucharest, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Triazole fungicides are widely used in agriculture but may pose risks to human health through occupational, accidental, or environmental exposure. This systematic review aimed to evaluate the toxicity of ten European Union-approved triazole fungicides in rodent models and cell lines. A total of 70 studies were included, reporting quantitative in vivo oral, dermal, or inhalation toxicity in mammals or quantitative in vitro cytotoxicity in human or mammalian cell lines; the exclusion criteria comprised publications not in English or not accessible. Literature searches were conducted in Web of Science, Google Scholar, and the Pesticide Properties DataBase (PPDB), and risk of bias in included studies was assessed using ToxRTool. Due to heterogeneity in study designs, reporting formats, and endpoints, data were synthesized descriptively. Quantitative endpoints included LD

Indexed as

ADMEfungicidal triazole class pesticideshuman health toxicityin vitro cytotoxicityin vivo mammal studiesmolecular mechanismsnetwork analysis

Identifiers

PMID41440755
PMCPMC12733837

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.