ArticleJournal of functional biomaterials2025
In Vitro Study Regarding Cytotoxic and Inflammatory Response of Gingival Fibroblasts to a 3D-Printed Resin for Denture Bases.
Article in Journal of functional biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Design, synthesis, and biological evaluation of quinolin-2-one/thiazole hybrids as multi-targeted antiproliferative agents inducing caspase-dependent apoptosis.Scientific reports · 2026Article
- In Vitro Cytotoxicity of Three Dimethacrylate-Based Photopolymer Resins for 3D-Printed Dental Restorations: A Qualitative Morphological Screening on Human Fibroblasts.Journal of functional biomaterials · 2026Article
- Comparative Cytotoxicity of Commercially Pure Titanium, Silver-Palladium and Nickel-Chromium Alloys on Human Gingival Fibroblasts: An In Vitro Study.Journal of clinical medicine · 2026Article
- Biocompatibility and Cell Death Mechanisms Induced by PMMA-Based Dental Materials in Gingival Fibroblasts and OECM-1 Tumor Cells.Dentistry journal · 2026Article
- Evaluation of Post-Processing Time's Influence on Biocompatibility of 3D-Printed Denture Base Resins.Journal of functional biomaterials · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In clinical practice, the selection of dental material is a crucial factor for the final success of the treatment, regarding mechanical properties and biocompatibility. Our study aimed to evaluate the cytotoxicity of a PMMA dental resin used for denture base fabrication and to investigate whether autophagy might be involved in the response of the exposed cells. In vitro tests, such as assessments of cell viability and metabolism, nitric oxide (NO), lactate dehydrogenase (LDH), and autophagy, were conducted. The results showed that exposure to PMMA-based material decreased cell viability by 35% after 24 h and 36% after 48 h. NO levels increased by 10% after 24 h and 2% after 48 h. LDH levels increased by 8% after 24 h and 31% after 48 h. Within the limits of this present study, our results suggest a significant activation of autophagy in the exposed fibroblasts, possibly as a survival mechanism, based on the viability and cell metabolic activity results.
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Registered trials
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