Evidence map›Paper›PMID 41440548›Full record

Observational studyMedical sciences (Basel, Switzerland)2025

Determinants of Entero-Invasive and Non-Entero-Invasive Diarrheagenic Bacteria Among HIV-Positive and HIV-Negative Adults in Ghana.

Hagen Frickmann, Fred Stephen Sarfo, Betty Roberta Norman, Albert Dompreh, Shadrack Osei Asibey, Richard Boateng, Veronica Di Cristanziano, Tafese Beyene Tufa, Ulrike Loderstädt, Ramona Binder and 4 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Medical sciences (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hagen FrickmannDepartment of Microbiology and Hospital Hygiene, Bundeswehr Hospital Hamburg, 22049 Hamburg, Germany.ORCID 0000-0002-8967-9528
Fred Stephen SarfoDepartment of Medicine, Komfo Anokye Teaching Hospital, Kumasi 00233, Ghana.
Betty Roberta NormanDepartment of Medicine, Komfo Anokye Teaching Hospital, Kumasi 00233, Ghana.ORCID 0000-0002-4075-5972
Albert DomprehDepartment of Clinical Microbiology, Komfo Anokye Teaching Hospital, Kumasi 00233, Ghana.
Shadrack Osei AsibeyDepartment of Medicine, Komfo Anokye Teaching Hospital, Kumasi 00233, Ghana.
Richard BoatengDepartment of Clinical Microbiology, Komfo Anokye Teaching Hospital, Kumasi 00233, Ghana.ORCID 0000-0003-3599-9136
Veronica Di CristanzianoInstitute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.ORCID 0000-0003-1604-8386
Tafese Beyene TufaAsella Referral and Teaching Hospital, College of Health Sciences, Arsi University, Asella P.O. Box 04, Ethiopia.ORCID 0000-0002-9505-9341
Ulrike LoderstädtInstitute of Infection Control and Infectious Diseases, University Medical Center Göttingen, 37075 Göttingen, Germany.
Ramona BinderLaboratory Medicine and Transfusion Medicine Department, IMD Laboratory Greifswald, 17493 Greifswald, Germany.
Andreas Erich ZautnerInstitute of Laboratory Medicine and Microbiology & Vaccination Center, Klinikum Würzburg Mitte, Campus Juliusspital, 97070 Würzburg, Germany.ORCID 0000-0003-0984-013X
Tom LueddeDepartment of Gastroenterology, Hepatology and Infectious Diseases, University Hospital and Medical Faculty of the Heinrich Heine University, 40225 Düsseldorf, Germany.ORCID 0000-0002-6288-8821
Torsten FeldtHirsch Institute of Tropical Medicine (HITM), Heinrich Heine University, Asella P.O. Box 04, Ethiopia.ORCID 0000-0002-6755-4492
Kirsten Alexandra EberhardtDepartment of Gastroenterology, Hepatology and Infectious Diseases, University Hospital and Medical Faculty of the Heinrich Heine University, 40225 Düsseldorf, Germany.ORCID 0000-0002-1002-0326

Funding

German Federal Ministry of Education and Research 01KA1102German Ministry of Defense 36K2-S-45 1922
6 · The paper itself

Abstract

objectivesThis observational and cross-sectional study investigated differential associations between entero-invasive and non-entero-invasive enteric pathogens and HIV infection, considering socioeconomic, clinical and immunological aspects. In a Ghanaian population with a high prevalence of enteric pathogens, stool samples from people living with HIV (PLWH) were screened for

methodsStool samples from PLWH (with and without antiretroviral therapy) and HIV-negative controls were analyzed by real-time PCR for the presence and quantity of the selected enteropathogens. Results were correlated with socioeconomic, clinical, and immunological parameters.

resultsThe presence of

conclusionsThis explorative, hypothesis-forming study suggests species- or pathovar-specific associations between enteric bacterial pathogens and HIV-related immunosuppression. Observed relationships with clinically apparent diarrhea largely align with findings from sub-Saharan African children, except for a more pronounced association between diarrhea and

Indexed as

DiarrheaHIV InfectionsAdultCD4 Lymphocyte CountCross-Sectional StudiesFecesFemaleGhanaHumansMaleMiddle AgedShigellaArcobacter butzleriCampylobacterenteroaggregativeenteropathogenicenterotoxigenicEscherichia coliHIVimmunosuppressionSalmonellaShigella

Identifiers

PMID41440548
PMCPMC12735155

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.