ArticleMedical sciences (Basel, Switzerland)2025
Risk of Chronic Kidney Disease and Implications in Patients with Atrial Fibrillation for the Development of Major Adverse Cardiovascular Events with Machine Learning.
Article in Medical sciences (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Cardiovascular Comorbidities and Advanced Chronic Kidney Disease in Hospitalized Patients with Multiple Myeloma: A Single-Center Retrospective Cohort Study.Diseases (Basel, Switzerland) · 2026Article
- Sex-Specific Health and Economic Benefits in Older Women at Risk of Atrial Fibrillation: A Proof-of-Concept Evaluation of an AI-Enabled Strategy for Early Thromboembolic Risk Detection.Journal of clinical medicine · 2026Article
- Inflammation, Endothelial Dysfunction, and Platelet Dysregulation in Atrial Fibrillation with Chronic Kidney Disease: Toward a Biology-Informed Anticoagulation Strategy.Life (Basel, Switzerland) · 2026Review
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Authors and funding
9 authors.
Funding
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Abstract
backgroundAtrial fibrillation (AF) and chronic kidney disease (CKD) often overlap and may amplify cardiovascular risk. Whether renal dysfunction should be incorporated into composite cardiovascular endpoints in AF remains uncertain. We aimed to quantify AF-associated risk of MACE and evaluate the incremental prognostic value of kidney measures (eGFR and albuminuria) to inform composite outcomes and clinical management.
methodsWe performed a retrospective, community-based cohort study of 40,297 adults aged 65-95 years. Individuals with incident AF (
resultsIncident AF was associated with higher risk of MACE (HR 3.52), CKD (HR 1.97) and all-cause mortality (HR 1.14). CKD was nearly twice more frequent in AF than in non-AF (30.9% vs. 14.5%;
conclusionsNewly diagnosed AF confers a substantial excess risk of MACE and its components. The consistent eGFR and albuminuria in AF support considering clinically meaningful renal endpoints within composite outcomes and prioritizing integrated cardiorenal management. These findings provide actionable evidence to refine risk stratification and endpoint selection in AF research and care.
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