ArticleMedical sciences (Basel, Switzerland)2025
Selected Serum Biomarkers in Patients with Relapsing-Remitting Multiple Sclerosis-A 3-Year Prospective Pilot Study.
Article in Medical sciences (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe aim of this study was to evaluate the significance of serum concentrations of the inflammatory marker osteopontin, the blood-brain barrier damage marker occludin, and the neurodegeneration marker neurofilament light chain (NFL) in patients with relapsing-remitting multiple sclerosis (RRMS) for predicting disease activity and progression.
methodsThis prospective cohort study enrolled 150 patients with RRMS. Initial serum levels of NFL, occludin, and osteopontin were compared between patients who met or did not meet the no evidence of disease activity (NEDA) criteria and its components (relapses, magnetic resonance imaging activity, and Expanded Disability Status Scale progression) within 36 months of observation. Independent factors affecting study outcomes at month 36 were identified from baseline data, including age, gender, initial prognostic profile, and serum levels of NFL, occludin, and osteopontin, as well as treatment type.
resultsWe found lower osteopontin concentrations in patients receiving highly effective treatment compared with those receiving platform therapies (13.64 ± 5.41 ng/mL, CI 11.75-15.53 vs. 17.33 ± 8.00 ng/mL, CI 15.66-18.61;
conclusionsSerum levels of NFL, osteopontin, and occludin may serve as biomarkers of disease activity in patients with RRMS. The clinical relevance of these biomarkers should be confirmed through repeated serum marker assessments in MS patients and validation studies involving larger sample sizes.
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