Evidence map›Paper›PMID 41440233›Full record

ArticleCurrent oncology (Toronto, Ont.)2025

The Risk of Breast Cancer According to Mutation Type and Position in Carriers of a Pathogenic Variant in

Joanne Kotsopoulos, Adriana I Apostol, Kelly Metcalfe, Dimitri Jorgji, Cezary Cybulski, Jacek Gronwald, Jan Lubinski, Pal Moller, Raymond H Kim, Amber Aeilts and 15 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Current oncology (Toronto, Ont.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Joanne KotsopoulosWomen's College Research Institute, University of Toronto, Toronto, ON M5S 1A1, Canada.
Adriana I ApostolWomen's College Research Institute, University of Toronto, Toronto, ON M5S 1A1, Canada.ORCID 0009-0008-4614-9261
Kelly MetcalfeWomen's College Research Institute, University of Toronto, Toronto, ON M5S 1A1, Canada.
Dimitri JorgjiWomen's College Research Institute, University of Toronto, Toronto, ON M5S 1A1, Canada.ORCID 0009-0003-9648-4213
Cezary CybulskiDepartment of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, 70-204 Szczecin, Poland.ORCID 0000-0002-2819-3057
Jacek GronwaldDepartment of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, 70-204 Szczecin, Poland.ORCID 0000-0002-3643-2871
Jan LubinskiDepartment of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, 70-204 Szczecin, Poland.ORCID 0000-0003-2931-3003
Pal MollerInstitute of Cancer Research, Department of Tumour Biology, The Norwegian Radium Hospital, Oslo University Hospital, 0379 Oslo, Norway.
Raymond H KimPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4, Canada.ORCID 0000-0002-2147-8674
Amber AeiltsDivision of Human Genetics, The Ohio State University Medical Center, Comprehensive Cancer Center, Columbus, OH 43210, USA.ORCID 0000-0001-8907-7853
Teresa Ramón Y CajalDepartment of Medical Oncology, Hospital de la Santa Creu i Sant Pau, 08025 Barcelona, Spain.ORCID 0000-0003-3490-3585
Tuya PalVanderbilt-Ingram Cancer Center, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.ORCID 0000-0001-8009-2475
Louise BordeleauDepartment of Oncology, Juravinski Cancer Centre and McMaster University, Hamilton, ON L8V 5C2, Canada.
Beth Y KarlanDepartment of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0002-9451-2933
Christian F SingerDepartment of Obstetrics and Gynecology and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.
William D FoulkesMcGill Program in Cancer Genetics, Department of Oncology, McGill University, Montreal, QC H3A 0G4, Canada.
Fergus J CouchDivision of Experimental Pathology and Laboratory Medicine, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.
Dana ZakalikCancer Genetics Program, Beaumont Hospital, Royal Oak, MI 48073, USA.
Robert FruscioDepartment of Medicine and Surgery, University of Milan Bicocca, 20126 Monza, Italy.ORCID 0000-0001-5688-2194
Nadine TungBeth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Ping SunWomen's College Research Institute, University of Toronto, Toronto, ON M5S 1A1, Canada.
Alvaro N MonteiroMoffitt Cancer Centre, Tampa, FL 33612, USA.ORCID 0000-0002-8448-4801
Steven A NarodWomen's College Research Institute, University of Toronto, Toronto, ON M5S 1A1, Canada.ORCID 0000-0001-5798-0626
Mohammad R AkbariWomen's College Research Institute, University of Toronto, Toronto, ON M5S 1A1, Canada.
Hereditary Breast Cancer Clinical Study Group

Funding

The Role of CHFR in Tumorigenesis and Paclitaxel-Sensitivity in Breast CancerP50CA116201 · NCI · MAYO CLINIC ROCHESTER · PI Fergus Joseph Couch · 2005 to 2026
$49.9M
Resolving the cancer relevance of predisposition gene mutationsR35CA253187 · NCI · MAYO CLINIC ROCHESTER · PI Fergus Joseph Couch · 2020 to 2026
$5.8M
Breast Cancer Research Foundation n/aCanada Research Chair n/aNCI NIH HHS P50 CA116201NCI NIH HHS R35 CA253187NIH HHS R35 CA253187, P50 CA116201
6 · The paper itself

Abstract

backgroundCarriers of a pathogenic variant (PV) in

methods

resultsA total of 3677

conclusionsAlthough our data suggests some variability in penetrance based on specific

Indexed as

Breast NeoplasmsGenes, BRCA1Genetic Predisposition to DiseaseAdolescentAdultAgedAged, 80 and overExonsFemaleHeterozygoteHumansLongitudinal StudiesMiddle AgedMutationProspective StudiesRisk FactorsBRCA variantbreast cancerexonnucleotide positionrisk

Identifiers

PMID41440233
PMCPMC12731516

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.