Evidence map›Paper›PMID 41440199›Full record

ArticleCurrent oncology (Toronto, Ont.)2025

Does Cardiopulmonary Bypass Affect Outcomes in Nephrectomy with Level III/IV Caval Thrombectomy for Renal Cell Carcinoma?

John V Dudinec, Alireza Ghoreifi, Justin Refugia, Sriram Deivasigamani, Michael Ivey, Alexandra E Hunter, Farshad S Moghaddam, Abigail R Benkert, Joseph J Fantony, Adam R Williams and 2 more

Abstract read
In one paragraph

Article in Current oncology (Toronto, Ont.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

John V DudinecDepartment of Urology, Duke University Medical Center, Durham, NC 27705, USA.
Alireza GhoreifiDepartment of Urology, Duke University Medical Center, Durham, NC 27705, USA.ORCID 0000-0002-7368-7240
Justin RefugiaDepartment of Urology, Duke University Medical Center, Durham, NC 27705, USA.
Sriram DeivasigamaniDepartment of Urology, Duke University Medical Center, Durham, NC 27705, USA.
Michael IveyDepartment of Urology, Duke University Medical Center, Durham, NC 27705, USA.ORCID 0009-0009-5512-2404
Alexandra E HunterDepartment of Urology, Duke University Medical Center, Durham, NC 27705, USA.
Farshad S MoghaddamDepartment of Urology, University of Washington, Seatle, WA 98195, USA.
Abigail R BenkertDivision of Thoracic and Cardiovascular Surgery, Department of Surgery, Duke University Medical Center, Durham, NC 27705, USA.ORCID 0000-0001-5220-7706
Joseph J FantonyDepartment of Urology, Duke University Medical Center, Durham, NC 27705, USA.
Adam R WilliamsDivision of Thoracic and Cardiovascular Surgery, Department of Surgery, Duke University Medical Center, Durham, NC 27705, USA.
Ankeet ShahDepartment of Urology, Duke University Medical Center, Durham, NC 27705, USA.
Michael R AbernDepartment of Urology, Duke University Medical Center, Durham, NC 27705, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radical nephrectomy with inferior vena cava (IVC) thrombectomy is a technically complex procedure. Cardiopulmonary bypass (CPB) is frequently employed for managing high-level thrombi, yet its impact on surgical outcomes remains uncertain. This study evaluated the outcomes of radical nephrectomy with level III/IV thrombectomy with or without CPB. We retrospectively reviewed records of patients with renal cell carcinoma and level III/IV (Mayo classification) thrombi who underwent open radical nephrectomy and IVC thrombectomy at our center between January 2000 and December 2023. Perioperative and survival outcomes were compared between patients in the CPB and non-CPB groups. Multivariable regression identified clinical factors associated with all-grade complications and survival. Primary and secondary outcomes were 90-day complications and overall survival. Fifty-seven patients were included: 30 (53%) in the CPB group and 27 (47%) in the non-CPB group. Within 90 days, overall complication and mortality rates were 49% and 10.5%; no statistically significant differences were observed between groups. In multivariable models, CPB was not independently associated with 90-day complications (odds ratio [OR] 0.55, 95% CI 0.13-2.12,

Indexed as

Carcinoma, Renal CellCardiopulmonary BypassKidney NeoplasmsNephrectomyThrombectomyVena Cava, InferiorAgedFemaleHumansMaleMiddle AgedRetrospective StudiesTreatment Outcomeinferior vena cavaradical nephrectomyrenal cell carcinomathrombectomy

Identifiers

PMID41440199
PMCPMC12731594

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.