Evidence map›Paper›PMID 41440120›Full record

ArticleBrain sciences2025

Core Body Temperature Negatively Correlates with Whole-Brain Gray Matter Volume: A Pilot Study in the Context of Global Warming.

Keisuke Kokubun, Kiyotaka Nemoto, Yoshimitsu Yamamoto, Ayumu Mitera, Yoshinori Yamakawa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Keisuke KokubunGraduate School of Management, Kyoto University, Kyoto 606-8501, Kyoto, Japan.ORCID 0000-0002-7440-5049
Kiyotaka NemotoDepartment of Medical Informatics and Management and Psychiatry, Institute of Medicine, University of Tsukuba, Tsukuba 305-8575, Ibaraki, Japan.ORCID 0000-0001-8623-9829
Yoshimitsu YamamotoMitsufuji Corporation, Kyoto 619-0237, Kyoto, Japan.
Ayumu MiteraMitsufuji Corporation, Kyoto 619-0237, Kyoto, Japan.
Yoshinori YamakawaGraduate School of Management, Kyoto University, Kyoto 606-8501, Kyoto, Japan.ORCID 0000-0002-7995-1794

Funding

ImPACT Program of Council for Science, Technology, and Innovation (Cabinet Office, Government of Japan) nilJSPS KAKENHI JP17H06151; JP25K15384
6 · The paper itself

Abstract

Global warming has been associated with various adverse effects on human physiology, yet its potential impact on brain structure remains largely unexplored. The present pilot study investigated the relationship between core body temperature and whole-brain gray matter volume (GMV) in healthy adults. Twenty-seven participants (19 males, 8 females; mean age = 38.6 ± 10.3 years) underwent MRI scanning and core temperature assessment. Correlation and partial correlation analyses were performed to examine the association between core body temperature and GMV, controlling for demographic and physiological covariates summarized by the first principal component. Core body temperature showed a significant negative correlation with whole-brain GMV (r = -0.496,

Indexed as

brain structurecore body temperatureenvironmental neuroscienceglobal warminggray matter volume (GMV)inflammationmagnetic resonance imaging (MRI)neural healthoxidative stresstemperature regulation

Identifiers

PMID41440120
PMCPMC12730599

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.