ArticleBrain sciences2025
Hormonal and Cytokine Imbalances Promote a Proinflammatory Profile in Institutionalized Elderly.
Article in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Establishment of reference intervals for plasma IL-6, IL-8, IL-10, and IL-1β in healthy adults from Lianyungang, Jiangsu, China: a single-center flow cytometry analysis.Frontiers in medicine · 2026Article
- Reference intervals for plasma IFN-α, TNF-α, IL-12p70, and IFN-γ by flow cytometry in healthy adults from eastern China: a single-center study.Frontiers in immunology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundAging is accompanied by chronic low-grade inflammation (inflammaging) and neuroendocrine-immune imbalance. This study evaluated blood concentrations of cortisol, melatonin, and Th1/Th2/Th17 cytokines in elderly individuals.
methodsA cross-sectional study was conducted, including institutionalized elderly individuals (
resultsInstitutionalized individuals showed higher IL-6 (
conclusionsInstitutionalization is associated with elevated blood hormone levels and an imbalanced cytokine pattern, indicating disruption of the neuroendocrine-immune network. These alterations align with the concept of inflammaging and highlight the impact of the living environment on immune-endocrine regulation in older adults.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.