Evidence map›Paper›PMID 41440030›Full record

ArticleCells2025

Preclinical Evaluation of the Assembly Modulator PAV-615 in a Mouse Model of

Jingfen Su, Jorge Alaiz Noya, Anuradha F Lingappa, Dennis Solas, Jimei Tong, Lillian Daughrity, Monica Castanedes-Casey, Aishe Kurti, Dennis W Dickson, Vishwanath R Lingappa and 2 more

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jingfen SuDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Jorge Alaiz NoyaDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Anuradha F LingappaProsetta Biosciences, Inc., San Francisco, CA 94107, USA.ORCID 0009-0006-8976-4382
Dennis SolasProsetta Biosciences, Inc., San Francisco, CA 94107, USA.
Jimei TongDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Lillian DaughrityDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Monica Castanedes-CaseyDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Aishe KurtiDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Dennis W DicksonDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Vishwanath R LingappaProsetta Biosciences, Inc., San Francisco, CA 94107, USA.
Leonard PetrucelliDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Yongjie ZhangDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-9900-4313

Funding

Technology and Remote Assessment CoreU19AG063911 · NIA · MAYO CLINIC ROCHESTER · PI ADAM L. BOXER · 2019 to 2026
$120.9M
Research Education ComponentP30AG062677 · NIA · MAYO CLINIC ROCHESTER · PI KEJAL KANTARCI · 2019 to 2026
$33.5M
Project 3: Neuropathology of the multi-proteinopathy of c9FTD/ALS.P01NS084974 · NINDS · MAYO CLINIC JACKSONVILLE · PI PETRUCELLI, LEONARD · 2014 to 2024
$17.6M
Human Biomarkers CoreU54NS123743 · NINDS · STANFORD UNIVERSITY · PI FRATTA, PIETRO, GITLER, AARON D. · 2021 to 2025
$8.2M
Investigating the role of TMEM106b genetics and pathology in Alzheimer’s disease, LATE and FTLDR01NS132330 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Keith A Josephs, LEONARD PETRUCELLI · 2023 to 2026
$4.3M
Bio-RaPID: Biomarkers and Rates of Progression In Dementia.R01AG089380 · NIA · MAYO CLINIC JACKSONVILLE · PI DAY, GREGORY SCOTT · 2024 to 2025
$4.1M
Poly(ADP-ribose) promotes the condensation and toxicity of C9orf72 arginine-rich dipeptide repeat proteinsR01NS117461 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Tania France Gendron, Yongjie Zhang · 2021 to 2026
$2.9M
Double-stranded RNA in neuronal cell death in Alzheimer's and related neurodegenerative diseasesR01AG085307 · NIA · UNIVERSITY OF COLORADO · PI CHARLES A HOEFFER, Christopher D. Link · 2024 to 2026
$2.3M
Expanding insights into FTD disease mechanismsR35NS137447 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI LEONARD PETRUCELLI · 2025 to 2026
$2.3M
Alzheimer's Disease Strategic Fund grant ADSF-24-1284327-CAssociation for Frontotemporal Degeneration Biomarkers Initiative NABrightFocus Foundation NACure Alzheimer's Fund NAFlorida Department of Health Ed and Ethel Moore Alzheimer's Disease Research Program NAKissick Family Foundation NANational Institutes of Health/National Institute of Neurological Disorders and Stroke U54NS123743, R35 NS137447, P01NS084974, R01NS132330 and R01NS117461National Institutes of Health/National Institute on Aging 5P30AG0062677, ALLFTD U19AG063911, R01AG089380 and R01AG085307NIA NIH HHS P30 AG062677NIA NIH HHS R01 AG085307NIA NIH HHS R01 AG089380NIA NIH HHS U19 AG063911NINDS NIH HHS P01 NS084974NINDS NIH HHS R01 NS117461NINDS NIH HHS R01 NS132330NINDS NIH HHS R35 NS137447NINDS NIH HHS U54 NS123743Robert Packard Center for ALS Research at Johns Hopkins NATarget ALS Foundation NA
6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal neurodegenerative diseases that share clinical and pathological features, as well as genetic causes. A G

Indexed as

Amyotrophic Lateral SclerosisC9orf72 ProteinFrontotemporal DementiaAnimalsDisease Models, AnimalDrug Evaluation, PreclinicalHumansMaleMiceMice, TransgenicC9orf72 Proteinamyotrophic lateral sclerosisanxiety-like behaviorassembly modulationataxin 2-positive stress granuleC9orf72dipeptide repeat proteinsfrontotemporal dementiaG4C2 repeat expansionhyperactivitymotor functionPAV-615phosphorylated TDP-43

Identifiers

PMID41440030
PMCPMC12732003

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.