Evidence map›Paper›PMID 41440029›Full record

ArticleCells2025

Liraglutide-Driven Weight Loss Modulates Placental Remodeling in Obese Pregnancies in Mice.

Natassia Rodrigo, Dunja Aksentijevic, Nikayla Patel, Carol A Pollock, Lana McClements, Sarah J Glastras

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Natassia RodrigoDiabetes and Obesity Research Group, Kolling Institute of Medical Research, Sydney, NSW 2065, Australia.
Dunja AksentijevicWilliam Harvey Research Institute, Barts and the London Faculty of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.ORCID 0000-0002-8480-6727
Nikayla PatelWilliam Harvey Research Institute, Barts and the London Faculty of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.ORCID 0000-0003-0672-0810
Carol A PollockDiabetes and Obesity Research Group, Kolling Institute of Medical Research, Sydney, NSW 2065, Australia.
Lana McClementsSchool of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW 2007, Australia.
Sarah J GlastrasDiabetes and Obesity Research Group, Kolling Institute of Medical Research, Sydney, NSW 2065, Australia.ORCID 0000-0002-9317-1348

Funding

Juvenile Diabetes Research Foundation JDRF Kickstart grantWellcome Trust
6 · The paper itself

Abstract

backgroundThe placenta stands at the maternal-fetal interface and is a key organ regulating the intrauterine environment. In pregnancies exposed to obesity, placental function, signaling, and nutrient handling are adversely altered. Pre-conception weight loss is a potential intervention to alter an obesogenic milieu of pregnancy, which we investigated in a mouse model of maternal obesity using diet or administration of the glucagon-like peptide-1 (GLP-1) receptor agonist liraglutide.

methodsPre-pregnancy weight loss in

results

conclusionsThese findings highlight the importance of dietary or pharmacological interventions in the pre- or immediate post-conception period, with pre-conception offering a critical window to reduce aberrant placental changes induced by obesity.

Indexed as

LiraglutideObesityPlacentaPregnancy in ObesityWeight LossAnimalsDiet, High-FatFemaleMiceMice, Inbred C57BLOxidative StressPregnancyLiraglutidedietliraglutideplacentapre-conceptionreproductive health

Identifiers

PMID41440029
PMCPMC12731410

What OpenQuestion holds

Texttitle and abstract
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.