The Cell Polarity Protein Scribble Is Involved in Maintaining the Structure of Neuromuscular Junctions, the Expression of Myosin Heavy Chain Genes, and Endocytic Recycling in Adult Skeletal Muscle Fibers.

Lea Gessler, Yongzhi Jian, Nam Anh Ngo, Said Hashemolhosseini

Abstract read

In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

4 authors.

Lea GesslerInstitute of Biochemistry, Medical Faculty, Friedrich-Alexander-University of Erlangen-Nürnberg, Fahrstraße 17, 91054 Erlangen, Germany.

Yongzhi JianInstitute of Biochemistry, Medical Faculty, Friedrich-Alexander-University of Erlangen-Nürnberg, Fahrstraße 17, 91054 Erlangen, Germany.ORCID 0009-0001-5114-5096

Nam Anh NgoInstitute of Biochemistry, Medical Faculty, Friedrich-Alexander-University of Erlangen-Nürnberg, Fahrstraße 17, 91054 Erlangen, Germany.

Said HashemolhosseiniInstitute of Biochemistry, Medical Faculty, Friedrich-Alexander-University of Erlangen-Nürnberg, Fahrstraße 17, 91054 Erlangen, Germany.ORCID 0000-0002-6564-5649

Funding

Deutsche Forschungsgemeinschaft HA3309/3-1, HA3309/6-1, and HA3309/7-1

6 · The paper itself

Abstract

The role of LAP proteins expressed in skeletal muscles (ERBIN, LANO, and SCRIBBLE) and at neuromuscular junctions (NMJs) remains largely unknown. Our previous data demonstrate that LAP proteins are differentially expressed in muscle cells, nerve endings, and terminal Schwann cells, though they are all expressed in myofibers and accumulate at NMJs. ERBIN and SCRIBBLE align with acetylcholine receptor clusters (CHRNs) at the NMJ. In vivo ablation of

Indexed as

EndocytosisMembrane ProteinsMuscle Fibers, SkeletalMyosin Heavy ChainsNeuromuscular JunctionAnimalsIntracellular Signaling Peptides and ProteinsMiceMice, KnockoutIntracellular Signaling Peptides and ProteinsMembrane ProteinsMyosin Heavy Chainsscrib protein, mouseErbinLanoLAPneuromuscular junctionScribScribbleskeletal muscle

Identifiers

PMID41440028

DOI10.3390/cells14242005

PMCPMC12731447

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.