Evidence map›Paper›PMID 41440026›Full record

ArticleCells2025

Metabolic Astrocytic Support with Decanoic Acid Enhances Energy Metabolism in Alzheimer's Disease Models.

Aishat O Ameen, Maja B Rindshøj, Katarina Stoklund Dittlau, Karin Borges, Kristine K Freude, Blanca I Aldana

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Aishat O AmeenDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.ORCID 0000-0002-1297-3817
Maja B RindshøjDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.
Katarina Stoklund DittlauDepartment of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, DK-1870 Copenhagen, Denmark.ORCID 0000-0003-2776-2892
Karin BorgesSchool of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane 4072, Australia.ORCID 0000-0001-7448-0770
Kristine K FreudeDepartment of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, DK-1870 Copenhagen, Denmark.ORCID 0000-0001-9480-2386
Blanca I AldanaDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.ORCID 0000-0002-5027-1218

Funding

Alzheimerforeningen NADanmarks Frie Forskningsfond 1030-00285BDanmarks Frie Forskningsfond 2078-00002B
6 · The paper itself

Abstract

Alzheimer's disease (AD) is increasingly recognized as a disorder of cerebral energy metabolism, where impaired glucose utilization contributes to disease pathology. Medium-chain fatty acids (MCFAs), such as decanoic acid (C10), have emerged as promising metabolic substrates due to their ability to bypass glycolytic deficits and support mitochondrial function. In this study, we investigated the metabolic impact of C10 in the 5xFAD mouse model of AD and in human induced pluripotent stem cell (hiPSC)-derived astrocytes carrying familial AD mutations. Utilizing stable

Indexed as

Alzheimer DiseaseAstrocytesDecanoic AcidsEnergy MetabolismAnimalsBrainDisease Models, AnimalFemaleGlucoseHumansInduced Pluripotent Stem CellsMiceMice, Transgenicdecanoic acidDecanoic AcidsGlucose5xFAD mouseAlzheimer’s diseasebrain energy metabolismdecanoic acidhiPSC-derived astrocytesmedium-chain fatty acidsmitochondria

Identifiers

PMID41440026
PMCPMC12731942

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.