Evidence map›Paper›PMID 41440018›Full record

ArticleCells2025

Piezo1 Mechanosensor Expression in Rare Hematopoietic Cells Controls Systemic Inflammatory Response in Mice.

Shiv Vardan Singh, Anastasia Iris Karkempetzaki, Nasi Huang, Vipul C Chitalia, Saravanan Subramaniam, Katya Ravid

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shiv Vardan SinghDepartment of Medicine, and Whitaker Cardiovascular Institute, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.
Anastasia Iris KarkempetzakiDepartment of Medicine, and Whitaker Cardiovascular Institute, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.
Nasi HuangDepartment of Medicine, and Whitaker Cardiovascular Institute, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.ORCID 0000-0002-2708-5054
Vipul C ChitaliaRenal Section, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.ORCID 0000-0002-6663-6058
Saravanan SubramaniamDepartment of Pharmaceutical Sciences, School of Pharmacy, Massachusetts College of Pharmacy and Health Sciences, Boston, MA 02115, USA.ORCID 0000-0002-0194-5044
Katya RavidDepartment of Medicine, and Whitaker Cardiovascular Institute, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.ORCID 0000-0002-9918-3024

Funding

Megakaryocyte Mechanosensing Toward Platelet BiogenesisR01HL158670 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAVID, KATYA · 2021 to 2024
$1.6M
NHLBI NIH HHS R01 HL158670NIH HHS 1R01HL158670-04
6 · The paper itself

Abstract

Mutations in the Piezo1 mechanosensor are associated with blood cell anomalies. The objective of our study was to explore the role of Piezo1 in the development and function of the megakaryocyte (MK) lineage. To this end, PF4-Cre mice, bearing Cre recombinase under the control of the

Indexed as

Hematopoietic Stem CellsInflammationIon ChannelsMechanotransduction, CellularAnimalsCytokinesMegakaryocytesMiceMice, Inbred C57BLMice, KnockoutCytokinesIon ChannelsPiezo1 protein, mouseinflammatory responsemegakaryocytePiezo1platelet activation

Identifiers

PMID41440018
PMCPMC12732291

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.