Evidence map›Paper›PMID 41440010›Full record

ArticleCells2025

Alzheimer's Disease Risk Variants Interact with Amyloid-Beta to Modulate Monocyte Function.

Zena K Chatila, Elizabeth M Bradshaw

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Zena K ChatilaDivision of Translational Neurobiology, Department of Neurology, Columbia University Irving Medical Center, 630 West 168th Street, New York, NY 10032, USA.ORCID 0000-0002-4383-6305
Elizabeth M BradshawDivision of Translational Neurobiology, Department of Neurology, Columbia University Irving Medical Center, 630 West 168th Street, New York, NY 10032, USA.ORCID 0000-0002-6766-4325

Funding

Convergence of myeloid susceptibility protein function in Alzheimer's diseaseRF1AG058852 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRADSHAW, ELIZABETH M · 2018 to 2020
$2.9M
Investigating the convergence of AD genetics on lipid metabolism and microglia regulationR21AG073882 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI AREA GOMEZ, ESTELA, BRADSHAW, ELIZABETH M · 2021 to 2021
$431k
Alzheimer's Disease Genetic Risk and Microglial Innate Immune MemoryF30AG074618 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CHATILA, ZENA · 2021 to 2024
$200k
Alzheimer's Association DVT-14-321148NIA NIH HHS F30 AG074618NIA NIH HHS F30AG074618NIA NIH HHS R21 AG073882NIA NIH HHS RF1 AG058852NIA NIH HHS RF1AG058852
6 · The paper itself

Abstract

While genetics implicate a central role for dysregulated innate immunity in Alzheimer's disease (AD), the contributions of peripheral myeloid cells, such as monocytes, have been largely overlooked in favor of microglia. Here, we investigate whether AD-associated loci, specifically

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesGenetic Predisposition to DiseaseMonocytesFemaleHumansLeukocytes, MononuclearMaleMembrane GlycoproteinsMicrogliaPeptide FragmentsPhagocytosisPolymorphism, Single NucleotideReceptors, ImmunologicSialic Acid Binding Ig-like Lectin 3Amyloid beta-PeptidesCD33 protein, humanMembrane GlycoproteinsPeptide FragmentsReceptors, ImmunologicSialic Acid Binding Ig-like Lectin 3TREM2 protein, humanAmyloid-beta1-42 uptakeCD33human monocytesPU.1TREM2

Identifiers

PMID41440010
PMCPMC12731656

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.