Evidence map›Paper›PMID 41439942›Full record

ArticleDiseases (Basel, Switzerland)2025

Association Between Obesity and Serum Leptin Levels in Brazilian Female Shift Workers.

Raquel Toresan Andretta, Janaína Cristina da Silva, Anderson Garcez, Ingrid Stähler Kohl, Karina Giane Mendes, Thais Basso, Maria Teresa Anselmo Olinto, Heloísa Theodoro

Abstract read
In one paragraph

Article in Diseases (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Raquel Toresan AndrettaPost-Graduate Program in Health Sciences, University of Caxias do Sul (UCS), Caxias do Sul 95070-560, RS, Brazil.
Janaína Cristina da SilvaPost-Graduate Program in Collective Health, University of Vale do Rio dos Sinos (Unisinos), São Leopoldo 93022-750, RS, Brazil.
Anderson GarcezPost-Graduate Program in Medical Sciences: Endocrinology, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre 90610-264, RS, Brazil.ORCID 0000-0003-1111-4890
Ingrid Stähler KohlPost-Graduate Program in Medical Sciences: Endocrinology, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre 90610-264, RS, Brazil.ORCID 0000-0001-8765-0759
Karina Giane MendesPost-Graduate Program in Health Sciences, University of Caxias do Sul (UCS), Caxias do Sul 95070-560, RS, Brazil.
Thais BassoPost-Graduate Program in Health Sciences, University of Caxias do Sul (UCS), Caxias do Sul 95070-560, RS, Brazil.
Maria Teresa Anselmo OlintoPost-Graduate Program in Medical Sciences: Endocrinology, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre 90610-264, RS, Brazil.ORCID 0000-0002-3950-4594
Heloísa TheodoroPost-Graduate Program in Health Sciences, University of Caxias do Sul (UCS), Caxias do Sul 95070-560, RS, Brazil.

Funding

National Council for Scientific and Technological Development 406161/2021-6
6 · The paper itself

Abstract

backgroundLeptin is a hormone that plays a crucial role in regulating energy homeostasis and it is associated with adiposity. Women engaged in work shifts are often exposed to circadian disruption and metabolic changes that may contribute to increased adiposity and hormonal imbalance. Thus, this study aimed to investigate the association between general and abdominal obesity and serum leptin levels among female shift workers.

methodsThis cross-sectional study included a sample of 302 female employees from a group of plastic manufacturing industries in southern Brazil. Serum leptin levels were measured, with values > 15.2 ng/mL classified as elevated. General obesity (body mass index ≥ 30 kg/m

resultsThe mean age of participants was 35.4 ± 10.1 years. The mean serum leptin concentration in the sample was 33.6 ng/mL (95% Confidence Interval [CI]: 30.6-36.6), and the prevalence of altered serum leptin levels was 78.1% (95% CI: 73.5-82.8). After adjustment for potential confounders, women with obesity showed a 63% higher probability of having elevated leptin levels (Prevalence Ratio [PR] = 1.63; 95% CI: 1.32-2.02;

conclusionsObesity was independently associated with elevated serum leptin levels among female shift workers, suggesting that excess adiposity remains a key determinant of leptin dysregulation in this population.

Indexed as

leptinobesityshift workwomen’s health

Identifiers

PMID41439942
PMCPMC12732115

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.