Evidence map›Paper›PMID 41439867›Full record

ArticleBiomimetics (Basel, Switzerland)2025

Core-Shell Silk Fibroin Hydrogel Microneedles Functionalized with Antibody-Binding Domains for Transdermal Delivery.

Min Ki Lee, Ae Sol Lee, Chang Sup Kim

Abstract read
In one paragraph

Article in Biomimetics (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Min Ki LeeGraduate School of Biochemistry, Yeungnam University, Gyeongsan 38541, Republic of Korea.
Ae Sol LeeDepartment of Chemical & Biochemical Engineering, Dongguk University, Seoul 04620, Republic of Korea.
Chang Sup KimDepartment of Chemical & Biochemical Engineering, Dongguk University, Seoul 04620, Republic of Korea.ORCID 0000-0001-5850-3450

Funding

Ministry of Science and ICT RS-2024-00348647
6 · The paper itself

Abstract

Microneedle (MN) patches comprise a promising platform for transdermal delivery of macromolecular therapeutics. However, achieving sufficient mechanical strength for skin penetration while maintaining high biocompatibility and efficient antibody loading remains a major challenge. In this study, we designed and developed a core-shell-structured hydrogel MN patch composed of a silk fibroin core and a protein-based shell layer for antibody loading and potential transdermal release. The latter was constructed using a fusion protein consisting of the B and C domains of

Indexed as

antibody binding domaincore–shell structurehydrogel microneedle patchsilk fibrointransdermal delivery

Identifiers

PMID41439867
PMCPMC12731075

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.