Evidence map›Paper›PMID 41439854›Full record

Trial reportAdvances in respiratory medicine2025

Effectiveness and Safety of Glycopyrronium-Formoterol-Budesonide Triple Therapy in Chronic Obstructive Pulmonary Disease (AIR-FORCE): An Open-Label Multi-Centric Phase 4 Study.

Anjali R Nath, Adesh Kumar, Amit Suresh Bhate, Bharat Mehrotra, Deependra Kumar Rai, Vijay Kumar Barge, Divya Bhojwani, Sagar Bhagat, Sumit Bhushan, Saiprasad Patil and 1 more

Abstract readMulticenter StudyClinical Trial, Phase IV
In one paragraph

Trial report in Advances in respiratory medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Anjali R NathCitizen Hospital, Bangalore 560002, India.
Adesh KumarRespiratory Medicine, Uttar Pradesh University of Medical Sciences (UPUMS), Etawah 206130, India.
Amit Suresh BhateMedicine Department, Jeevan Rekha Hospital, Belagavi 590002, India.
Bharat MehrotraNew Leelamani Hospital, Kanpur 208001, India.
Deependra Kumar RaiRespiratory Medicine, All India Institute of Medical Sciences (AIIMS), Patna 801507, India.
Vijay Kumar BargeMedicine Department, Rajarshee Chhatrapati Shahu Maharaj Government Medical College Chhatrapati Pramila Raje Hospital (RCSM), Kolhapur 416012, India.
Divya BhojwaniGlobal Medical Affairs, Glenmark Pharmaceuticals, Ltd., Mumbai 400099, India.ORCID 0009-0003-7111-6844
Sagar BhagatGlobal Medical Affairs, Glenmark Pharmaceuticals, Ltd., Mumbai 400099, India.
Sumit BhushanGlobal Medical Affairs, Glenmark Pharmaceuticals, Ltd., Mumbai 400099, India.ORCID 0009-0003-8940-8175
Saiprasad PatilGlobal Medical Affairs, Glenmark Pharmaceuticals, Ltd., Mumbai 400099, India.
Hanmant BarkateGlobal Medical Affairs, Glenmark Pharmaceuticals, Ltd., Mumbai 400099, India.

Funding

Glenmark Pharmaceuticals (India) NA
6 · The paper itself

Abstract

Chronic obstructive pulmonary disease (COPD) is a major health burden in India with limited real-world data on triple inhaler therapy. This prospective, open-label, multi-center, single-arm, phase 4 study (October 2023-August 2024) assessed the effectiveness and safety of glycopyrronium/formoterol fumarate/budesonide (GFB) triple therapy, administered as metered-dose inhaler (MDI) or dry-powder inhaler (DPI), in Indian COPD patients. Symptomatic patients aged ≥40 years with minimum one exacerbation in the past year and receiving dual or monotherapy were included. GFB was delivered as MDI or DPI based on physician and patient preference. Primary outcomes were changes from baseline in trough forced expiratory volume in 1 s (FEV

Indexed as

Bronchodilator AgentsBudesonide, Formoterol Fumarate Drug CombinationFormoterol FumarateGlycopyrrolatePulmonary Disease, Chronic ObstructiveAdministration, InhalationAdultAgedDrug Therapy, CombinationDry Powder InhalersFemaleForced Expiratory VolumeHumansIndiaMaleMetered Dose InhalersBronchodilator AgentsBudesonide, Formoterol Fumarate Drug CombinationFormoterol FumarateGlycopyrrolateCOPDdry-powder inhalereffectivenessGFBglycopyrronium/formoterol/budesonidemetered-dose inhalerreal-worldsafety

Identifiers

PMID41439854
PMCPMC12729428

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.