Evidence map›Paper›PMID 41439803›Full record

SynthesisIET systems biology

The Accuracy in Rupture Risk Prediction of Intracranial Aneurysms by Artificial Intelligence Algorithms Using Imaging Data From CTA and DSA: A Systematic Review and Meta-Analysis.

Ruixuan Zhang, Ruibo Liu, He Ma, Guangxin Chu, Ligang Chen, Guobiao Liang, Liang Ma, Hai Jin

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in IET systems biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ruixuan ZhangThe College of Medicine and Biological Information Engineering, Northeastern University, Shenyang, China.ORCID 0009-0006-9300-9144
Ruibo LiuThe College of Medicine and Biological Information Engineering, Northeastern University, Shenyang, China.
He MaThe College of Medicine and Biological Information Engineering, Northeastern University, Shenyang, China.
Guangxin ChuDepartment of Neurosurgery, General Hospital of Northern Theater Command, Shenyang, China.
Ligang ChenDepartment of Neurosurgery, General Hospital of Northern Theater Command, Shenyang, China.
Guobiao LiangDepartment of Neurosurgery, General Hospital of Northern Theater Command, Shenyang, China.
Liang MaDepartment of Neurosurgery, General Hospital of Northern Theater Command, Shenyang, China.
Hai JinDepartment of Neurosurgery, General Hospital of Northern Theater Command, Shenyang, China.

Funding

Liaoning Provincial Science and Technology Plan Joint Program 2022020786-JH2/1015Liaoning Provincial Science and Technology Plan Joint Program 2025110227-JH2/1018Liaoning Revitalization Talents Program XLYC2403134
6 · The paper itself

Abstract

Ruptured intracranial aneurysms (IAs) are the leading cause of aSAH. There are limitations in combining traditional imaging methods (CTA and DSA) and clinical scores (PHASES) to predict IAs rupture risk, whereas artificial intelligence (AI) algorithms show potential. This meta-analysis evaluated AI algorithm performance for predicting IAs rupture risk based on CTA and DSA. As of February 2025, we searched Web of Science, PubMed, Scopus, and Embase, extracting TP, FP, FN, and TN from included studies. The combined sensitivity, specificity, and AUC were synthesised with a bivariate random-effects model. Subgroup analyses were performed. PROSPERO: CRD420251008866. Twenty studies (13,232 patients, 14,344 IAs) reported pooled sensitivity 0.84 (95% CI: 0.80-0.87), specificity 0.82 (95% CI: 0.78-0.86), and AUC 0.90 (95% CI: 0.87-0.92) with substantial heterogeneity. Subgroup analyses showed DOR in the DSA versus CTA groups (DSA 23.55, CTA 22.21) with persistent heterogeneity. The clinical-morphological-radiomics group had DOR 18.76 without heterogeneity. By publication year, 2021 group had a lower DOR (12.99) versus 2022 (23.03) versus 2023 (26.98), with low heterogeneity. AI algorithms predicting IAs rupture risk based on CTA and DSA demonstrate high diagnostic accuracy and have potential to advance the field.

Indexed as

AlgorithmsAneurysm, RupturedAngiography, Digital SubtractionArtificial IntelligenceComputed Tomography AngiographyIntracranial AneurysmHumansbraindata analysismedical diagnostic computingpatient diagnosisreviews

Identifiers

PMID41439803
PMCPMC12729478

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.